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Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload
Li H.5; He C.3; Feng J.5; Zhang Y.5; Tang Q.5; Bian Z.5; Bai X.5; Zhou H.5; Jiang H.5; Heximer S.P.1; Qin M.5; Huang H.5; Liu P.P.4; Huang C.5
2010-08-03
Source PublicationProceedings of the National Academy of Sciences of the United States of America
ISSN10916490 00278424
Volume107Issue:31Pages:13818-13823
Abstract

The development of cardiac hypertrophy in response to increased hemodynamic load and neurohormonal stress is initially a compensatory response that may eventually lead to ventricular dilation and heart failure. Regulator of G protein signaling 5 (Rgs5) is a negative regulator of G protein-mediated signaling by inactivating Gα(q) and Gα(i), which mediate actions of most known vasoconstrictors. Previous studies have demonstrated that Rgs5 expresses among various cell types within mature heart and showed high levels of Rgs5 mRNA in monkey and human heart tissue by Northern blot analysis. However, the critical role of Rgs5 on cardiac remodeling remains unclear. To specifically determine the role of Rgs5 in pathological cardiac remodeling, we used transgenic mice with cardiac-specific overexpression of human Rgs5 gene and Rgs5 mice. Our results demonstrated that the transgenic mice were resistant to cardiac hypertrophy and fibrosis through inhibition of MEK-ERK1/2 signaling, whereas the Rgs5 mice displayed the opposite phenotype in response to pressure overload. These studies indicate that Rgs5 protein is a crucial component of the signaling pathway involved in cardiac remodeling and heart failure.

KeywordErk1/2 Mek1/2 Rgs5 Signal Transduction
DOI10.1073/pnas.1008397107
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000280605900049
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Cited Times [WOS]:85   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi H.; Huang C.
Affiliation1.University of Toronto Faculty of Medicine
2.Wuhan University
3.Massachusetts General Hospital
4.University Health Network University of Toronto
5.Hubei General Hospital
Recommended Citation
GB/T 7714
Li H.,He C.,Feng J.,et al. Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload[J]. Proceedings of the National Academy of Sciences of the United States of America,2010,107(31):13818-13823.
APA Li H..,He C..,Feng J..,Zhang Y..,Tang Q..,...&Huang C..(2010).Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload.Proceedings of the National Academy of Sciences of the United States of America,107(31),13818-13823.
MLA Li H.,et al."Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload".Proceedings of the National Academy of Sciences of the United States of America 107.31(2010):13818-13823.
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