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Omega-3 polyunsaturated fatty acids protect neural progenitor cells against oxidative injury
Liu Q.2; Wu D.2; Ni N.2; Ren H.2; Luo C.2; He C.2; Kang J.-X.1; Wan J.-B.2; Su H.2
2014
Source PublicationMarine Drugs
ISSN16603397
Volume12Issue:5Pages:2341-2356
Abstract

The omega-3 polyunsaturated fatty acids (ω-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), derived mainly from fish oil, play important roles in brain development and neuroplasticity. Here, we reported that application of ω-3 PUFAs significantly protected mouse neural progenitor cells (NPCs) against HO-induced oxidative injury. We also isolated NPCs from transgenic mice expressing the Caenorhabditis elegans fat-1 gene. The fat-1 gene, which is absent in mammals, can add a double bond into an unsaturated fatty acid hydrocarbon chain and convert ω-6 to ω-3 fatty acids. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining showed that a marked decrease in apoptotic cells was found in fat-1 NPCs after oxidative injury with HO as compared with wild-type NPCs. Quantitative RT-PCR and Western blot analysis demonstrated a much higher expression of nuclear factor erythroid 2-related factor 2 (Nrf2), a master transcriptional factor for antioxidant genes, in fat-1 NPCs. The results of the study provide evidence that ω-3 PUFAs resist oxidative injury to NPCs. © 2014 by the authors; licensee MDPI.

KeywordOxidative Stress Fat-1 Dha Neural Progenitor Cells
DOI10.3390/md12052341
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000337160500001
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Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSu H.
Affiliation1.Massachusetts General Hospital
2.Universidade de Macau
Recommended Citation
GB/T 7714
Liu Q.,Wu D.,Ni N.,et al. Omega-3 polyunsaturated fatty acids protect neural progenitor cells against oxidative injury[J]. Marine Drugs,2014,12(5):2341-2356.
APA Liu Q..,Wu D..,Ni N..,Ren H..,Luo C..,...&Su H..(2014).Omega-3 polyunsaturated fatty acids protect neural progenitor cells against oxidative injury.Marine Drugs,12(5),2341-2356.
MLA Liu Q.,et al."Omega-3 polyunsaturated fatty acids protect neural progenitor cells against oxidative injury".Marine Drugs 12.5(2014):2341-2356.
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