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Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation
Wang M.; Zhang X.-J.; Liu F.; Hu Y.; He C.; Li P.; Su H.; Wan J.-B.
2015
Source PublicationJournal of Functional Foods
ISSN17564646
Volume19Pages:214-224
Abstract

Effects of saponins from leaves of Panax notoginseng (LPNS) against alcoholic liver injury were evaluated, and their probable molecular mechanisms were further elucidated in a mouse model of chronic-plus-single-binge ethanol feeding. Alcohol exposure dramatically increased plasma levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triacylglycerol (TG) and endotoxin; these elevations were attenuated by treatment with LPNS at a dose of 100 or 300 mg/kg. LPNS was also found to suppress thiobarbituric acid reactive substances (TBARS) production, enhance glutathione (GSH) level and superoxide dismutase (SOD) activity in liver. The protective of LPNS against oxidative stress was associated with down-regulation of hepatic cytochrome P450 2E1 (CYP2E1), and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and haem oxygenase-1 (HO-1). Additionally, LPNS ameliorated gut leakiness via upregulating the expressions of tight junction proteins, and suppressed endotoxin-mediated inflammation via down-regulating toll-like receptor-4 (TLR-4), CD14 and p-NF-κB p65. These results demonstrate that treatment with LPNS effectively protects against alcoholic liver injury through reducing ethanol-induced oxidative stress and ameliorating gut-derived endotoxin-mediated inflammation.

KeywordAlcoholic Liver Injury Ginsenoside Rb1 Ginsenoside Rb2 Ginsenoside Rb3 Ginsenoside Rc Ginsenoside Rd Gut-derived Endotoxin Inflammation Oxidative Stress Saponins From The Leaves Of Panax Notoginseng
DOI10.1016/j.jff.2015.09.029
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000365634100020
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Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWan J.-B.
AffiliationUniversidade de Macau
Recommended Citation
GB/T 7714
Wang M.,Zhang X.-J.,Liu F.,et al. Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation[J]. Journal of Functional Foods,2015,19:214-224.
APA Wang M..,Zhang X.-J..,Liu F..,Hu Y..,He C..,...&Wan J.-B..(2015).Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation.Journal of Functional Foods,19,214-224.
MLA Wang M.,et al."Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation".Journal of Functional Foods 19(2015):214-224.
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