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Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage
Zhang X.-J.; He C.; Li P.; Su H.; Wan J.-B.
2015
Source PublicationJournal of Functional Foods
ISSN17564646
Volume15Pages:580-592
Abstract

Hepatic ischemia/reperfusion (I/R), characterized by severe inflammation and cell death, causes significant liver damage, and there are no effective approaches to prevent this pathological condition. We evaluated the potentially protective functions of ginsenoside Rg1 in hepatic I/R injury and the underlying mechanisms. A mouse hepatic I/R model was established by 60 min of induced ischemia followed by 0, 6, 12 or 24 h of reperfusion. Ginsenoside Rg1 (20 mg/kg/day) significantly promoted hepatic function and suppressed liver necrosis and inflammatory responses. Mechanistically, the JNK/MAPK signaling was dramatically diminished by ginsenoside Rg1. Furthermore, we unexpectedly found that only the cytotoxicity induced by inflammation, rather than oxidative stress, was significantly inhibited by ginsenoside Rg1 in vitro, and this inhibition was almost completely abolished by treatment with a specific JNK activator, anisomycin. Thus, ginsenoside Rg1 exerts protective effects against hepatic I/R in a JNK signaling-dependent manner.

KeywordGinsenoside Rg1 Hepatic Ischemia/reperfusion Inflammation Apoptosis Jnk Signaling
DOI10.1016/j.jff.2015.04.010
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000355240800056
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWan J.-B.
AffiliationUniversidade de Macau
Recommended Citation
GB/T 7714
Zhang X.-J.,He C.,Li P.,et al. Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage[J]. Journal of Functional Foods,2015,15:580-592.
APA Zhang X.-J.,He C.,Li P.,Su H.,&Wan J.-B..(2015).Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage.Journal of Functional Foods,15,580-592.
MLA Zhang X.-J.,et al."Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage".Journal of Functional Foods 15(2015):580-592.
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