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α-Glucosidase inhibitory activity and structural characterization of polysaccharide fraction from Rhynchosia minima root
Jia X.; Hu J.; He M.; Zhang Q.; Li P.; Wan J.; He C.
2017
Source PublicationJournal of Functional Foods
ISSN17564646
Volume28Pages:76-82
Abstract

Rhynchosia minima root, a renowned traditional Chinese medicinal herb, has been shown to exhibit multiple therapeutic activities. In this study, the α-glucosidase inhibitory activity of R. minima root polysaccharide fractions (PRM1, PRM3 and PRM5) is evaluated. PRM3 displays an excellent inhibitory activity with an IC value of 8.85 mg/mL, which is similar to that of acarbose, a positive control compound that has been applied for the control of postprandial hyperglycemia. PRM3 is a homogeneous fraction with an average molecular weight of 97.3 kDa. The results of methylation analysis, periodate oxidation and nuclear magnetic resonance (NMR) spectra reveal that the repeating units of PRM3 are mainly composed of (1 → 3,4)-α-Arap, (1 → 4,6)-β-Galp, (1 → 2,4)-β-Rhap, (1 → 3,4)-β-GalpA, T-α-Araf and T-α-Galp residues. Moreover, triple helix stereo-configuration has been proven to exist in PRM3. In summary, the strong α-glucosidase inhibitory activity and unique structural feature of PRM3 suggest that it could have a potential application in functional foods.

KeywordChemical Structure Polysaccharide Rhynchosia Minima Root Α-glucosidase Inhibitory Activity
DOI10.1016/j.jff.2016.10.026
URLView the original
Indexed BySCI
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000392885000009
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Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHe C.
AffiliationUniversidade de Macau
Recommended Citation
GB/T 7714
Jia X.,Hu J.,He M.,et al. α-Glucosidase inhibitory activity and structural characterization of polysaccharide fraction from Rhynchosia minima root[J]. Journal of Functional Foods,2017,28:76-82.
APA Jia X..,Hu J..,He M..,Zhang Q..,Li P..,...&He C..(2017).α-Glucosidase inhibitory activity and structural characterization of polysaccharide fraction from Rhynchosia minima root.Journal of Functional Foods,28,76-82.
MLA Jia X.,et al."α-Glucosidase inhibitory activity and structural characterization of polysaccharide fraction from Rhynchosia minima root".Journal of Functional Foods 28(2017):76-82.
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