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Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice
Wang M.2; Zhang X.-J.2; Feng R.2; Jiang Y.1; Zhang D.-Y.1; He C.2; Li P.2; Wan J.-B.2
2017-10-30
Source PublicationChinese Medicine (United Kingdom)
ISSN17498546
Volume12Issue:1
Abstract

Background: Penthorum chinense Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis. The aims of the present study were to evaluate the probable properties of the aqueous extract of PCP on carbon tetrachloride (CCl)-induced acute liver injury in mice. Methods: C57BL/6 mice were orally administered an aqueous extract of PCP (5.15 and 10.3 g/kg BW) or silymarin (100 mg/kg) once daily for 1 week prior to CCl exposure. Silymarin serves as a positive drug to validate the effectivenes of PCP. Results: A single dose of CCl exposure caused severe acute liver injury in mice, as evidenced by the elevated serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alanine phosphatase (ALP), and the increased TUNEL-positive cells in liver, which were remarkably ameliorated by the pretreatment of PCP. PCP was also found to decrease the levels of malondialdehyde (MDA), restore the glutathione (GSH) and enhance the activities of superoxide dismutase (SOD) and catalase (CAT) in the liver. In addition, the pretreatment of PCP inhibited the degradation of hepatic cytochrome P450 2E1 (CYP2E1), up-regulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its target proteins in CCl-treated mice. Conclusion: Results indicated that the pretreatment of PCP (10.3 g/kg BW) effectively protected against CCl-induced acute liver injury, which was comparable to efficacy of silymarin (100 mg/kg). This hepatoprotective effects might be attributed to amelioration of CCl-induced oxidative stress via activating Nrf2 signaling pathway.

KeywordCarbon Tetrachloride Hepatotoxicity Nuclear Factor E2-related Factor 2 Oxidative Stress Penthorum Chinense Pursh
DOI10.1186/s13020-017-0153-x
URLView the original
Indexed BySCI
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000414206700002
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被引频次[WOS]:8   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Affiliation1.Sichuan New Lotus Traditional Chinese Herb Limited Company
2.Universidade de Macau
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GB/T 7714
Wang M.,Zhang X.-J.,Feng R.,et al. Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice[J]. Chinese Medicine (United Kingdom),2017,12(1).
APA Wang M..,Zhang X.-J..,Feng R..,Jiang Y..,Zhang D.-Y..,...&Wan J.-B..(2017).Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice.Chinese Medicine (United Kingdom),12(1).
MLA Wang M.,et al."Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice".Chinese Medicine (United Kingdom) 12.1(2017).
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