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Material Basis of Chinese Herbal Formulas Explored by Combining Pharmacokinetics with Network Pharmacology
Pei L.2; Bao Y.2; Liu S.2; Zheng J.2; Chen X.1
2013-02-28
Source PublicationPLoS ONE
ISSN19326203
Volume8Issue:2
Abstract

The clinical application of Traditional Chinese medicine (TCM), using several herbs in combination (called formulas), has a history of more than one thousand years. However, the bioactive compounds that account for their therapeutic effects remain unclear. We hypothesized that the material basis of a formula are those compounds with a high content in the decoction that are maintained at a certain level in the system circulation. Network pharmacology provides new methodological insights for complicated system studies. In this study, we propose combining pharmacokinetic (PK) analysis with network pharmacology to explore the material basis of TCM formulas as exemplified by the Bushen Zhuanggu formula (BZ) composed of Psoralea corylifolia L., Aconitum carmichaeli Debx., and Cnidium monnieri (L.) Cuss. A sensitive and credible liquid chromatography tandem mass spectrometry (LC-MS/MS) method was established for the simultaneous determination of 15 compounds present in the three herbs. The concentrations of these compounds in the BZ decoction and in rat plasma after oral BZ administration were determined. Up to 12 compounds were detected in the BZ decoction, but only 5 could be analyzed using PK parameters. Combined PK results, network pharmacology analysis revealed that 4 compounds might serve as the material basis for BZ. We concluded that a sensitive, reliable, and suitable LC-MS/MS method for both the composition and pharmacokinetic study of BZ has been established. The combination of PK with network pharmacology might be a potent method for exploring the material basis of TCM formulas. © 2013 Pei et al.

DOI10.1371/journal.pone.0057414
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000315524900085
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Universidade de Macau
2.Shanghai University of Traditional Chinese Medicine
Recommended Citation
GB/T 7714
Pei L.,Bao Y.,Liu S.,et al. Material Basis of Chinese Herbal Formulas Explored by Combining Pharmacokinetics with Network Pharmacology[J]. PLoS ONE,2013,8(2).
APA Pei L.,Bao Y.,Liu S.,Zheng J.,&Chen X..(2013).Material Basis of Chinese Herbal Formulas Explored by Combining Pharmacokinetics with Network Pharmacology.PLoS ONE,8(2).
MLA Pei L.,et al."Material Basis of Chinese Herbal Formulas Explored by Combining Pharmacokinetics with Network Pharmacology".PLoS ONE 8.2(2013).
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