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Target network analysis of adiponectin, a multifaceted adipokine
Chen X.2
2013-05-01
Source PublicationJournal of Cellular Biochemistry
ISSN07302312 10974644
Volume114Issue:5Pages:1145-1152
Abstract

Application of network analysis to dissect the potential molecular mechanisms of biological processes and complicated diseases has been the new trend in biology and medicine in recent years. Among which, the protein-protein interactions (PPI) networks attract interests of most researchers. Adiponectin, a cytokine secreted from adipose tissue, participates in a number of metabolic processes, including glucose regulation and fatty acid metabolism and involves in a series of complicated diseases from head to toe. Hundreds of proteins including many identified and potential drug targets have been reported to be involved in adiponectin related signaling pathways, which comprised a complicated regulation network. Therapeutic target database (TTD) provides extensive information about the known and explored therapeutic protein targets and the signaling pathway information. In this study, adiponectin associated drug targets based PPI was constructed and its topological properties were analyzed, which might provide some insight into the dissection of adiponectin action mechanisms and promote adiponectin signaling based drug target identification and drug discovery. Copyright © 2012 Wiley Periodicals, Inc.

KeywordAdiponectin Clinical Tried Drug Target Network Analysis Research Drug Target Successful Drug Target
DOI10.1002/jcb.24457
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000316332200020
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Zunyi Medical College
2.Universidade de Macau
Recommended Citation
GB/T 7714
Chen X.. Target network analysis of adiponectin, a multifaceted adipokine[J]. Journal of Cellular Biochemistry,2013,114(5):1145-1152.
APA Chen X..(2013).Target network analysis of adiponectin, a multifaceted adipokine.Journal of Cellular Biochemistry,114(5),1145-1152.
MLA Chen X.."Target network analysis of adiponectin, a multifaceted adipokine".Journal of Cellular Biochemistry 114.5(2013):1145-1152.
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