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Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation
Kong Q.2; Sun F.1; Chen X.3
2013-06-01
Source PublicationCell Journal
ISSN22285814 22285806
Volume15Issue:2Pages:160-165
Abstract

Objective: Herb combination has been very popular in traditional medical prescriptions such as Traditional Chinese Medicine (TCM). Persistent efforts and attempts have been made to dissect the action mode of TCM in recent years, which has provided certain evidence for inter-herbal interactions. However, the interactions among different components in a single herb have been largely neglected. Materials and Methods: In this experimental study, the interactions among different components of a single herb were explored. The effect of three main sesquiterpenes (germacrone, curdione, furanodiene) isolated from Curcuma WenyujinY.H.Chenet C Ling on MDA-MB-231 and MCF-7 breast cancer cell proliferation alone or in combination with a fixed-dose-combination was investigated. Results: Furanodiene significantly inhibited cancer cell proliferation while germacrone and curdione showed no effect. Germacrone enhanced furanodiene's anti-proliferative effect. Curdione showed no effect on furanodiene's anti-proliferative effect but partly reversed the anti-proliferative effect of germacrone and furanodiene combined. The morphological and mitochondrial membrane potential (ΔΨm) changes showed similar results. However, they demonstrated complicated interactions on the expression of apoptotic-related proteins and key signal transduction proteins. Conclusion: Unpredictable and complex interactions among different components in Curcuma WenyujinY.H.Chenet C Ling may exist. The intra-herb interactions should be taken into consideration when attempts are made to interpret the art of TCM formulation or other similar recipes.

KeywordBreast Cancer Chinese Medicine Fixed-dose-combination Intra-herbal Drug Interactions Proliferation
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000338399200009
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Xizang Minzu University
2.Chinese Academy of Medical Sciences
3.Universidade de Macau
Recommended Citation
GB/T 7714
Kong Q.,Sun F.,Chen X.. Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation[J]. Cell Journal,2013,15(2):160-165.
APA Kong Q.,Sun F.,&Chen X..(2013).Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation.Cell Journal,15(2),160-165.
MLA Kong Q.,et al."Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation".Cell Journal 15.2(2013):160-165.
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