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A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats
Huang M.-Q.1; Xu W.1; Wu S.-S.1; Lu J.-J.2; Chen X.-P.2
2013-08-01
Source PublicationFood and Chemical Toxicology
ISSN02786915 18736351
Volume58Pages:318-323
Abstract

Alismatis Rhizoma has been used in East Asia as a traditional treatment for various illnesses and symptoms, and the presence of protostane-type triterpenes has been claimed to provide health benefits. To investigate the subchronic toxicity of triterpene-enriched extract from Alismatis Rhizoma (TEAR), a 90-day oral toxicity study was conducted in rats. Sprague-Dawley rats were randomly divided into four groups (10 rats/sex/group) and received doses of 0, 360, 720, and 1440. mg/kg/d of TEAR for 90. days. Daily clinical observations as well as weekly measurement of body weight and food consumption were conducted. Blood samples were obtained on day 91 to measure changes in hematology and biochemistry. Urine samples were collected on days 0 and 91 for urinalysis. At necropsy, selected organs were weighed and recorded, and histological examination was performed. No mortality or obvious treatment-related clinical signs, hematology, urinalysis parameters, and macroscopic or microscopic examinations were observed. Differences in weight gain, food consumption, biochemistry, and relative organ weight between the treated group and the control group were not considered treatment-related. On the basis of these findings, the no-observed-adverse-effect level for TEAR was 1440. mg/kg/d in both sexes. © 2013 Elsevier Ltd.

KeywordAlismatis Rhizoma Rats Subchronic Toxicity Triterpenes Water Plantain Root
DOI10.1016/j.fct.2013.05.009
URLView the original
Indexed BySCI
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000322099100042
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Fujian University of Traditional Chinese Medicine
2.Universidade de Macau
3.Zhejiang Chinese Medical University
Recommended Citation
GB/T 7714
Huang M.-Q.,Xu W.,Wu S.-S.,et al. A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats[J]. Food and Chemical Toxicology,2013,58:318-323.
APA Huang M.-Q.,Xu W.,Wu S.-S.,Lu J.-J.,&Chen X.-P..(2013).A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats.Food and Chemical Toxicology,58,318-323.
MLA Huang M.-Q.,et al."A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats".Food and Chemical Toxicology 58(2013):318-323.
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