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Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d -galactosamin/lipopolysacchride-induced liver injury in rats
Li W.2; Shi J.2; Papa F.1; Maggi F.1; Chen X.2
2016-05-18
Source PublicationNatural Product Research
ISSN14786427 14786419
Volume30Issue:10Pages:1162-1165
Abstract

Isofuranodiene is a natural sesquiterpene rich occurring in Smyrnium olusatrum, a forgotten culinary herb which was marginalised after the domestication of the improved form of celery. Our recent data showed that isofuranodiene inhibited the proliferation and induced apoptosis in cancer cells. In this study, we investigated its protective effect on d-galactosamine/lipopolysacchride (GalN/LPS)-induced liver injury in SD rats. Oral administration of isofuranodiene (20 and 50 mg/kg) dramatically inhibited GalN/LPS-induced serum elevation of aspartate aminotransferase, alanine aminotransferase and malondialdehyde levels, and significantly ameliorated liver injury as evidenced by the histological improvement in H&E staining. Furthermore, isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1β, IL-6 and inducible nitric oxide synthase in liver tissues. The results from this study showed that isofuranodiene protects GalN/LPS-induced liver injury in SD rats and suggested that it may be a potential functional food ingredient for the prevention and treatment of liver diseases.

KeywordGalactosamine/lipopolysaccharide Hepatoprotective Isofuranodiene Rats
DOI10.1080/14786419.2015.1041139
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000373635600009
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Università degli Studi di Camerino
2.Zunyi Medical College
3.Universidade de Macau
Recommended Citation
GB/T 7714
Li W.,Shi J.,Papa F.,et al. Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d -galactosamin/lipopolysacchride-induced liver injury in rats[J]. Natural Product Research,2016,30(10):1162-1165.
APA Li W.,Shi J.,Papa F.,Maggi F.,&Chen X..(2016).Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d -galactosamin/lipopolysacchride-induced liver injury in rats.Natural Product Research,30(10),1162-1165.
MLA Li W.,et al."Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d -galactosamin/lipopolysacchride-induced liver injury in rats".Natural Product Research 30.10(2016):1162-1165.
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