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The Chemical Constituents and the Hepato-protective Effect of the Essential Oil of Ferulago campestris (Besser) Grecescu (Apiaceae)
Li W.2; Papa F.1; Shi J.2; Maggi F.1; Chen X.2
2016-10-02
Source PublicationJournal of Essential Oil-Bearing Plants
ISSN0972060X
Volume19Issue:7Pages:1701-1708
Abstract

Ferulago campestris (Besser) Grecescu (Apiaceae), a perennial herb, has been traditionally used for the treatment of intestinal worms, haemorrhoids, ulcers, snake bites, as well as headache and diseases of the spleen. We distilled the essential oil of F. campestris (OFC) and investigated its protective effect on D-galactosamine/lipopolysacchride (GalN/LPS) induced liver injury in rats. The chemical constituents of OFC were determined by GC-FID and GC-MS. SD rats were treated orally with or without OFC (20, 50 mg/kg) for three consecutive days and then challenged with GalN/LPS for eight hours. The serum concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) were determined with commercial kits and the liver injury was examined by H&E staining. The mRNA expression of IL-1β, IL-6, and inducible nitric oxide synthase (iNOS) in liver tissues were determined by real-time PCR. The major fraction of OFC was given by monoterpene hydrocarbons (78.8 %) such as myrcene (33.4 %) α-pinene (23.0 %) and γ-terpinene (10.9 %). Oral administration of OFC dramatically inhibited GalN/LPS-induced serum elevation of AST, ALT, and MDA levels, and significantly ameliorated liver injury. Furthermore, OFC treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1β, IL-6, and inducible nitric oxide synthase (iNOS) in liver tissues. OFC protect GalN/LPS-induced liver injury in rats possibly by decreasing oxidative stress and inhibiting cytokines.

KeywordCytokine Essential Oil Ferulago Campestris (Besser) Grecescu (Apiaceae) Galactosamine/ Lipopolysaccharide
DOI10.1080/0972060X.2015.1121117
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences
WOS SubjectPlant Sciences
WOS IDWOS:000392637400012
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Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Università degli Studi di Camerino
2.Zunyi Medical College
3.Universidade de Macau
Recommended Citation
GB/T 7714
Li W.,Papa F.,Shi J.,et al. The Chemical Constituents and the Hepato-protective Effect of the Essential Oil of Ferulago campestris (Besser) Grecescu (Apiaceae)[J]. Journal of Essential Oil-Bearing Plants,2016,19(7):1701-1708.
APA Li W.,Papa F.,Shi J.,Maggi F.,&Chen X..(2016).The Chemical Constituents and the Hepato-protective Effect of the Essential Oil of Ferulago campestris (Besser) Grecescu (Apiaceae).Journal of Essential Oil-Bearing Plants,19(7),1701-1708.
MLA Li W.,et al."The Chemical Constituents and the Hepato-protective Effect of the Essential Oil of Ferulago campestris (Besser) Grecescu (Apiaceae)".Journal of Essential Oil-Bearing Plants 19.7(2016):1701-1708.
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