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Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy
Chang, Kaiwen1,3; Liu, Yubin1; Hu, Dehong2; Qi, Qiaofang1,3; Gao, Duyang1; Wang, Yating1; Li, Dongliang1; Zhang, Xuanjun1; Zheng, Hairong2; Sheng, Zonghai2; Yuan, Zhen1
2018-02-28
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:8Pages:7012-7021
Abstract

Theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, most photothermal agents are limited by their instability and low photothermal conversion efficiency. In this study, we report new conjugated polymer dots (Pdots) as multifunctional agents for photoacoustic (PA) imaging-guided PTT. The novel 4,8-bis [5-(2-ethylhexyl)thiophen-2-yl]-2,6-bis(trimethylstannyl)benzo [1,2-b:4,5-b']dithiophene-6,6'-dibromo-N,N'-(2-ethylhexyl)isoindigo (BDT-IID) Pdots are readily fabricated though nanoreprecipitation and can absorb strongly in the 650-700 nm region. Furthermore, the BDT-IID Pdots possess a stable nanostructure and an extremely low biotoxicity. In particular, its photothermal conversion efficiency can be up to 45%. More importantly, our in vivo results exhibit that the BDT-IID Pdots are able to offer concurrently enhanced PA contrast and sufficient photothermal effect. Consequently, the BDT-IID Pdots can be exploited as a unique theranostic nanoplatform for PA imaging-guided PTT of tumors, holding great promise for their clinical translational development.

KeywordConjugated Polymer Dots Multifunctional Agents Theranostic Nanoplatform Photoacoustic Imaging Photothermal Therapy
DOI10.1021/acsami.8b00759
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000426618000026
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Faculty of Health Sciences, University of Macau, Macau SAR 999708, China
2.Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese of Academy of Sciences, Shenzhen 518055, China
3.Key Laboratory of Medical Molecular Probes, Department of Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Chang, Kaiwen,Liu, Yubin,Hu, Dehong,et al. Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(8):7012-7021.
APA Chang, Kaiwen.,Liu, Yubin.,Hu, Dehong.,Qi, Qiaofang.,Gao, Duyang.,...&Yuan, Zhen.(2018).Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,10(8),7012-7021.
MLA Chang, Kaiwen,et al."Highly Stable Conjugated Polymer Dots as Multifunctional Agents for Photoacoustic Imaging-Guided Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 10.8(2018):7012-7021.
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