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Preparation and anti-bacterial properties of a temperature-sensitive gel containing silver nanoparticles
Chen M.1; Pan X.1; Wu H.1; Han K.1; Xie X.4; Wedge D.E.3; Repka M.A.2; Wu C.1
2011-05-01
Source PublicationPharmazie
ISSN00317144
Volume66Issue:4Pages:272-277
AbstractThe purpose of this study was to prepare a temperature-sensitive gel containing silver nanoparticles and to investigate its anti-bacterial properties in vitro. The aqueous gel was prepared using Pluronic F127 (18-22%) and Pluronic F68 (3-9%) in a cold method to obtain a proper gelation temperature at 37°C. Viscoelastic properties of the system were measured by rheological measurements and the physicochemical properties were evaluated by MJ-22 Dial-reflex metaloscope and Zetasizer Nano ZS90. The in vitro antimicrobial activity was evaluated by a disk diffusion test, minimum inhibitory concentration, and minimum bactericidal concentration. A temperature-sensitive gel containing silver nanoparticles with 20 wt% F127 and 6 wt% F68 had suitable fluidity at 25°C and was semi-solid at 37°C. Silver nanoparticle size averaged 78.0 nm. The gel optimized formulation achieved a suitable viscosity. The MIC and MBC of the gel ranged from 1.0 to 2.0 mg/L against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The activity of the gel against these three species was significantly enhanced (p < 0.05) compared to 400 mg/L Asimi standard. This optimized silver nanoparticle dosage form demonstrated a high potential for further development for the clinical treatment of bacterial vaginosis.
DOI10.1691/ph.2011.0158
URLView the original
Language英語
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Sun Yat-Sen University
2.University of Mississippi
3.USDA Agricultural Research Service, Washington DC
4.Guangdong Institute of Microbiology
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GB/T 7714
Chen M.,Pan X.,Wu H.,et al. Preparation and anti-bacterial properties of a temperature-sensitive gel containing silver nanoparticles[J]. Pharmazie,2011,66(4):272-277.
APA Chen M..,Pan X..,Wu H..,Han K..,Xie X..,...&Wu C..(2011).Preparation and anti-bacterial properties of a temperature-sensitive gel containing silver nanoparticles.Pharmazie,66(4),272-277.
MLA Chen M.,et al."Preparation and anti-bacterial properties of a temperature-sensitive gel containing silver nanoparticles".Pharmazie 66.4(2011):272-277.
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