UM
Optimization of the preparation process for an oral phytantriol-based Amphotericin B cubosomes
Wu C.5; Yang Z.5; Peng X.5; Tan Y.5; Chen M.5; Zhu X.2; Feng M.5; Xu Y.5
2011-10-11
Source PublicationJournal of Nanomaterials
ISSN16874110 16874129
Volume2011
AbstractIn order to develop an oral formation of Amphotericin B (AmB) using phytantriol- (PYT-) based cubosomes with desirable properties, homogenization conditions were firstly investigated to determine their effects on the morphological and dimensional characteristics of cubosomes. Under the optimized homogenization conditions of 1200bar for 9 cycles, cubosomes with reproducible, narrow particle size distribution and a mean particle size of 256.9nm±4.9nm were obtained. The structure of the dispersed cubosomes was revealed by SAXS (small-angle X-ray scattering) and Cryo-TEM (cryogenic transmission electron microscopy) as a bicontinuous cubic liquid crystalline phase with Pn3m geometry. To overcome the poor drug solubility and increase the drug-loading rate, a solubilization method was firstly used to develop cubosomes containing AmB. The encapsulation efficiency determined by HPLC assay was 87.8 ± 3.4 , and UV spectroscopy and stability studies in simulated gastric fluids further confirmed that AmB was successfully encapsulated in cubosomes. © 2011 Zhiwen Yang et al.
DOI10.1155/2011/308016
URLView the original
Language英語
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Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Gannan Medical College
2.Anton-Paar
3.Guangdong Research Center for Drug Delivery Systems
4.Guangdong Medical University
5.Sun Yat-Sen University
Recommended Citation
GB/T 7714
Wu C.,Yang Z.,Peng X.,et al. Optimization of the preparation process for an oral phytantriol-based Amphotericin B cubosomes[J]. Journal of Nanomaterials,2011,2011.
APA Wu C..,Yang Z..,Peng X..,Tan Y..,Chen M..,...&Xu Y..(2011).Optimization of the preparation process for an oral phytantriol-based Amphotericin B cubosomes.Journal of Nanomaterials,2011.
MLA Wu C.,et al."Optimization of the preparation process for an oral phytantriol-based Amphotericin B cubosomes".Journal of Nanomaterials 2011(2011).
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