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Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process
Tan Y.1; Yang Z.1; Pan X.1; Chen M.1; Feng M.1; Wang L.2; Liu H.2; Shan Z.1; Wu C.1
2012-05-10
Source PublicationInternational Journal of Pharmaceutics
ISSN03785173 18733476
Volume427Issue:2Pages:385-392
AbstractThe objective of this study was to investigate the stability and aerosolization of pressurized metered dose inhalers (pMDIs) containing thymopentin nanoparticles. Thymopentin nanoparticles, fabricated by a bottom-up process, were suspended in hydrofluoroalkane (HFA) 134a together with cineole and/or n-heptane to produce pMDI formulations. The stability study of the pMDIs obtained was carried out at ambient temperature for 6 months. The amount of thymopentin and the aerosolization properties of pMDIs were determined using high-performance liquid chromatography (HPLC) and a twin-stage impinger (TSI), respectively. Based on the results, thymopentin nanoparticles were readily suspended in HFA 134a with the aid of cineole and/or n-heptane to form physically stable pMDI formulations, and more than 98% of the labeled amount of thymopentin and over 50% of the fine particle fraction (FPF) of the pMDIs were achieved. During storage, it was found that for all pMDIs more than 97% of the labeled amount of thymopentin and FPF greater than 47% were achieved. Moreover, the size of thymopentin nanoparticles in propellant containing cineole and n-heptane showed little change. It is, therefore, concluded that the pMDIs comprising thymopentin nanoparticles developed in this study were stable and suitable for inhalation therapy for systemic action. © 2012 Elsevier B.V. All rights reserved.
KeywordAerosolization Fine particle fraction Nanoparticle Pressurized metered dose inhaler Stability Thymopentin
DOI10.1016/j.ijpharm.2012.02.002
URLView the original
Language英語
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Sun Yat-Sen University
2.Memorial University of Newfoundland
3.Universidade de Macau
Recommended Citation
GB/T 7714
Tan Y.,Yang Z.,Pan X.,et al. Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process[J]. International Journal of Pharmaceutics,2012,427(2):385-392.
APA Tan Y..,Yang Z..,Pan X..,Chen M..,Feng M..,...&Wu C..(2012).Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process.International Journal of Pharmaceutics,427(2),385-392.
MLA Tan Y.,et al."Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process".International Journal of Pharmaceutics 427.2(2012):385-392.
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