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Development of amphotericin B-loaded cubosomes through the SolEmuls technology for enhancing the oral bioavailability
Yang Z.2; Tan Y.2; Chen M.2; Dian L.2; Shan Z.2; Peng X.2; Wu C.2
2012-12-01
Source PublicationAAPS PharmSciTech
ISSN15309932
Volume13Issue:4Pages:1483-1491
AbstractThe oral administration of amphotericin B (AmB) has the major drawback of poor bioavailability. The aim of this work was to evaluate the potential of AmB-loaded cubosomes as an oral formulation with improved bioavailability. This manuscript firstly developed AmB-loaded cubosomes by using the SolEmuls technology. The encapsulation efficiency, the in vitro release, and stability studies in simulated gastrointestinal fluid were used to evaluate AmB-loaded cubosomes. The acute nephrotoxicity, bioavailability, and tissue distribution study of AmB-loaded cubosomes were assayed upon oral administration to rats. SAXS and cryo-TEM exhibited AmB-loaded cubosomes as a bicontinuous cubic liquid crystalline phase with Pn3m geometry. The encapsulation efficiency and the results of in vitro release and stability studies in simulated gastrointestinal fluid further demonstrated that AmB was successfully encapsulated in cubosomes. AmB-loaded cubosomal formulation orally administrated in rats did not show nephrotoxicity and its relative bioavailability was approximately 285% as compared to Fungizone®. The AmB-loaded cubosomal formulation presented an effective potential approach for enhancing the oral bioavailability of AmB. © 2012 American Association of Pharmaceutical Scientists.
Keywordamphotericin B cubosomes oral bioavailability SolEmuls technology
DOI10.1208/s12249-012-9876-2
URLView the original
Language英語
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Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Guangdong Research Center for Drug Delivery Systems
2.Sun Yat-Sen University
3.Shanghai Jiao Tong University
Recommended Citation
GB/T 7714
Yang Z.,Tan Y.,Chen M.,et al. Development of amphotericin B-loaded cubosomes through the SolEmuls technology for enhancing the oral bioavailability[J]. AAPS PharmSciTech,2012,13(4):1483-1491.
APA Yang Z..,Tan Y..,Chen M..,Dian L..,Shan Z..,...&Wu C..(2012).Development of amphotericin B-loaded cubosomes through the SolEmuls technology for enhancing the oral bioavailability.AAPS PharmSciTech,13(4),1483-1491.
MLA Yang Z.,et al."Development of amphotericin B-loaded cubosomes through the SolEmuls technology for enhancing the oral bioavailability".AAPS PharmSciTech 13.4(2012):1483-1491.
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