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Ultrasound-assisted extraction, antioxidant and anticancer activities of the polysaccharides from Rhynchosia minima root
Jia X.; Zhang C.; Hu J.; He M.; Bao J.; Wang K.; Li P.; Chen M.; Wan J.; Su H.; Zhang Q.; He C.
2015-11-23
Source PublicationMolecules
ISSN14203049
Volume20Issue:11Pages:20901-20911
Abstract

Box-Behnken design (BBD), one of the most common response surface methodology (RSM) methods, was used to optimize the experimental conditions for ultrasound-assisted extraction of polysaccharides from Rhynchosia minima root (PRM). The antioxidant abilities and anticancer activity of purified polysaccharide fractions were also measured. The results showed that optimal extraction parameters were as follows: ultrasound exposure time, 21 min; ratio of water to material, 46 mL/g; ultrasound extraction temperature, 63 °C. Under these conditions, the maximum yield of PRM was 16.95% ± 0.07%. Furthermore, the main monosaccharides of purified fractions were Ara and Gal. PRM3 and PRM5 exhibited remarkable DPPH radical scavenging activities and reducing power in vitro. PRM3 showed strong inhibitory activities on the growth of MCF-7 cells in vitro. The above results indicate that polysaccharides from R. minima root have the potential to be developed as natural antioxidants and anticancer ingredients for the food and pharmaceutical industries.

KeywordAnticancer Activity Antioxidant Activity Polysaccharide Rhynchosia Minima Root Ultrasound-assisted Extraction
DOI10.3390/molecules201119734
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000365925200041
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被引频次[WOS]:8   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorHe C.
AffiliationUniversidade de Macau
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GB/T 7714
Jia X.,Zhang C.,Hu J.,et al. Ultrasound-assisted extraction, antioxidant and anticancer activities of the polysaccharides from Rhynchosia minima root[J]. Molecules,2015,20(11):20901-20911.
APA Jia X..,Zhang C..,Hu J..,He M..,Bao J..,...&He C..(2015).Ultrasound-assisted extraction, antioxidant and anticancer activities of the polysaccharides from Rhynchosia minima root.Molecules,20(11),20901-20911.
MLA Jia X.,et al."Ultrasound-assisted extraction, antioxidant and anticancer activities of the polysaccharides from Rhynchosia minima root".Molecules 20.11(2015):20901-20911.
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