UM  > 中華醫藥研究院
PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer
Cai Y.4; Wang S.4; Wu M.1; Tsosie J.K.3; Xie X.2; Wan J.4; He C.4; Tian H.5; Chen X.5; Chen M.4
2016
Source PublicationRSC Advances
ISSN20462069
Volume6Issue:42Pages:35318-35327
Abstract

Mitoxantrone (MIT) is a promising candidate for cancer therapy, but the clinical application of MIT is hindered by its multidrug resistance (MDR) effect. Herein, amphiphilic poly(ϵ-caprolactone)-pluronic F68-poly(ϵ-caprolactone) (PFP) and PLGA-PEG-PLGA (PPP) polymers were designed to fabricate mixed micelles for the efficient delivery of MIT with reversed MDR effect. These mixed micelles (MIT-PFP/PPP micelles) exerted favorable particle size of 144.70 ± 10.52 nm and encapsulation efficiency of 56.69 ± 4.67%. Importantly, MIT-PFP/PPP micelles could strongly inhibit cell proliferation in MCF-7/ADR cells with the IC of 3.503 ± 0.163 μM for 24 h, which was about 7.7-fold lower than that of free MIT. The molecular mechanism of reversed MDR effect in MCF-7/ADR cells was ascribed to the downregulation of P-glycoprotein (P-gp) by MIT-PFP/PPP micelles resulting in enhanced anticancer efficacy. These findings suggest that MIT-PFP/PPP micelles have great potential for overcoming MDR effect by inhibiting the protein expression of P-gp in cancer cells.

DOI10.1039/c5ra27648a
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000374349600021
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen M.
Affiliation1.University of Florida
2.Sun Yat-Sen University
3.New Mexico Institute of Mining and Technology
4.Universidade de Macau
5.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cai Y.,Wang S.,Wu M.,et al. PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer[J]. RSC Advances,2016,6(42):35318-35327.
APA Cai Y..,Wang S..,Wu M..,Tsosie J.K..,Xie X..,...&Chen M..(2016).PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer.RSC Advances,6(42),35318-35327.
MLA Cai Y.,et al."PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer".RSC Advances 6.42(2016):35318-35327.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cai Y.]'s Articles
[Wang S.]'s Articles
[Wu M.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cai Y.]'s Articles
[Wang S.]'s Articles
[Wu M.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cai Y.]'s Articles
[Wang S.]'s Articles
[Wu M.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.