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Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases
Jiang Q.-W.2; Chen M.-W.4; Cheng K.-J.1; Yu P.-Z.3; Wei X.2; Shi Z.2
Source PublicationMedicinal Research Reviews
ISSN10981128 01986325
AbstractSteroidal alkaloids are a class of secondary metabolites isolated from plants, amphibians, and marine invertebrates. Evidence accumulated in the recent two decades demonstrates that steroidal alkaloids have a wide range of bioactivities including anticancer, antimicrobial, anti-inflammatory, antinociceptive, etc., suggesting their great potential for application. It is therefore necessary to comprehensively summarize the bioactivities, especially anticancer activities and mechanisms of steroidal alkaloids. Here we systematically highlight the anticancer profiles both in vitro and in vivo of steroidal alkaloids such as dendrogenin, solanidine, solasodine, tomatidine, cyclopamine, and their derivatives. Furthermore, other bioactivities of steroidal alkaloids are also discussed. The integrated molecular mechanisms in this review can increase our understanding on the utilization of steroidal alkaloids and contribute to the development of new drug candidates. Although the therapeutic potentials of steroidal alkaloids look promising in the preclinical and clinical studies, further pharmacokinetic and clinical studies are mandated to define their efficacy and safety in cancer and other diseases.
KeywordAnticancer effects Apoptosis Bioactivities Steroidal alkaloids
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Lishui Institute of Agricultural Sciences
2.Jinan University
3.Fudan University
4.Universidade de Macau
Recommended Citation
GB/T 7714
Jiang Q.-W.,Chen M.-W.,Cheng K.-J.,et al. Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases[J]. Medicinal Research Reviews,2016,36(1):119-143.
APA Jiang Q.-W.,Chen M.-W.,Cheng K.-J.,Yu P.-Z.,Wei X.,&Shi Z..(2016).Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases.Medicinal Research Reviews,36(1),119-143.
MLA Jiang Q.-W.,et al."Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases".Medicinal Research Reviews 36.1(2016):119-143.
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