| Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases | |
Jiang Q.-W.2; Chen M.-W.4 ; Cheng K.-J.1; Yu P.-Z.3; Wei X.2; Shi Z.2
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| 2016 | |
| Source Publication | Medicinal Research Reviews
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| ISSN | 10981128 01986325 |
| Volume | 36Issue:1Pages:119-143 |
| Abstract | Steroidal alkaloids are a class of secondary metabolites isolated from plants, amphibians, and marine invertebrates. Evidence accumulated in the recent two decades demonstrates that steroidal alkaloids have a wide range of bioactivities including anticancer, antimicrobial, anti-inflammatory, antinociceptive, etc., suggesting their great potential for application. It is therefore necessary to comprehensively summarize the bioactivities, especially anticancer activities and mechanisms of steroidal alkaloids. Here we systematically highlight the anticancer profiles both in vitro and in vivo of steroidal alkaloids such as dendrogenin, solanidine, solasodine, tomatidine, cyclopamine, and their derivatives. Furthermore, other bioactivities of steroidal alkaloids are also discussed. The integrated molecular mechanisms in this review can increase our understanding on the utilization of steroidal alkaloids and contribute to the development of new drug candidates. Although the therapeutic potentials of steroidal alkaloids look promising in the preclinical and clinical studies, further pharmacokinetic and clinical studies are mandated to define their efficacy and safety in cancer and other diseases. |
| Keyword | Anticancer effects Apoptosis Bioactivities Steroidal alkaloids |
| DOI | 10.1002/med.21346 |
| URL | View the original |
| Language | 英語 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Affiliation | 1.Lishui Institute of Agricultural Sciences 2.Jinan University 3.Fudan University 4.Universidade de Macau |
| Recommended Citation GB/T 7714 | Jiang Q.-W.,Chen M.-W.,Cheng K.-J.,et al. Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases[J]. Medicinal Research Reviews,2016,36(1):119-143. |
| APA | Jiang Q.-W.,Chen M.-W.,Cheng K.-J.,Yu P.-Z.,Wei X.,&Shi Z..(2016).Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases.Medicinal Research Reviews,36(1),119-143. |
| MLA | Jiang Q.-W.,et al."Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases".Medicinal Research Reviews 36.1(2016):119-143. |
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