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Endogenous n-3 fatty acids alleviate carbon-tetrachloride-induced acute liver injury in fat-1 transgenic mice
Feng R.2; Wang M.2; Yan C.1; Li P.2; Chen M.2; He C.2; Wan J.-B.2
2016
Source PublicationOxidative Medicine and Cellular Longevity
ISSN19420994 19420900
Volume2016
Abstract

n-3 polyunsaturated fatty acids (PUFAs) are beneficial for numerous models of liver diseases. The probable protective effects of n-3 PUFA against carbon-tetrachloride- (CCl-) induced acute liver injury were evaluated in a fat-1 transgenic mouse that synthesizes endogenous n-3 from n-6 PUFA. Fat-1 mice and their WT littermates were fed a modified AIN93 diet containing 10% corn oil and were injected intraperitoneally with a single dose of CCl or vehicle. CCl challenge caused severe liver injury in WT mice, as indicated by serum parameters and histopathological changes, which were remarkably ameliorated in fat-1 mice. Endogenous n-3 PUFA decreased the elevation of oxidative stress induced by CCl challenge, which might be attributed to the activation of Nrf2/keap1 pathway. Additionally, endogenous n-3 PUFA reduces hepatocyte apoptosis via suppressing MAPK pathway. These findings indicate that n-3 PUFA has potent protective effects against acute liver injury induced by CCl in mice, suggesting that n-3 PUFA can be used for the prevention and treatment of liver injury.

DOI10.1155/2016/7962948
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000388386800001
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHe C.; Wan J.-B.
Affiliation1.Guangdong College of Pharmacy
2.Universidade de Macau
Recommended Citation
GB/T 7714
Feng R.,Wang M.,Yan C.,et al. Endogenous n-3 fatty acids alleviate carbon-tetrachloride-induced acute liver injury in fat-1 transgenic mice[J]. Oxidative Medicine and Cellular Longevity,2016,2016.
APA Feng R..,Wang M..,Yan C..,Li P..,Chen M..,...&Wan J.-B..(2016).Endogenous n-3 fatty acids alleviate carbon-tetrachloride-induced acute liver injury in fat-1 transgenic mice.Oxidative Medicine and Cellular Longevity,2016.
MLA Feng R.,et al."Endogenous n-3 fatty acids alleviate carbon-tetrachloride-induced acute liver injury in fat-1 transgenic mice".Oxidative Medicine and Cellular Longevity 2016(2016).
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