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Cellulosic micelles as nanocapsules of liposoluble CdSe/ZnS quantum dots for bioimaging
Li Y.2; Zhang J.3; Guo Y.2; Chen M.3; Wang L.3; Sun R.2; Wang X.2
2016
Source PublicationJournal of Materials Chemistry B
ISSN2050750X 20507518
Volume4Issue:39Pages:6454-6461
AbstractNanostructures encapsulating multiple quantum dots (QDs) are of special interests for live cell imaging and biomolecular recognition due to their inherent signal amplification. In this study, a novel type of biomass-based nanomicelles was prepared and characterized for facile loading and solubilization of fluorescent hydrophobic CdSe/ZnS QDs in water. The biobased nanomicelles were formed by the self-assembly of amphiphilic cellulose-graft-poly (p-dioxanone) (MCC-g-PPDO) synthesized via homogeneous ring-opening polymerization in an ionic liquid. Through a simple physical loading method, multiple lipophilic CdSe/ZnS QDs can be simultaneously encapsulated in one MCC-g-PPDO micelle showing an obviously enlarged micelle size, whereas the loaded QDs exhibited a negligible change in their size and size distribution. The QDs-loaded cellulosic micelles exhibited good optical stability, narrow emission bandwidth as well as an acceptable quantum yield of ∼27%. Successful tumor cell internalization and negligible cytotoxicity were observed with these light-emitting cellulosic micelles. It was found that over 90% of the cells were viable after 24 h of exposure and the fluorescent signal inside the cells reached a maximum after 2 h of exposure. These QDs-loaded cellulosic nanomicelles derived from biomass are a promising candidate for bioimaging or other functional applications.
DOI10.1039/c6tb01534d
URLView the original
Language英語
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Dalian Polytechnic University
2.South China University of Technology
3.Universidade de Macau
Recommended Citation
GB/T 7714
Li Y.,Zhang J.,Guo Y.,et al. Cellulosic micelles as nanocapsules of liposoluble CdSe/ZnS quantum dots for bioimaging[J]. Journal of Materials Chemistry B,2016,4(39):6454-6461.
APA Li Y..,Zhang J..,Guo Y..,Chen M..,Wang L..,...&Wang X..(2016).Cellulosic micelles as nanocapsules of liposoluble CdSe/ZnS quantum dots for bioimaging.Journal of Materials Chemistry B,4(39),6454-6461.
MLA Li Y.,et al."Cellulosic micelles as nanocapsules of liposoluble CdSe/ZnS quantum dots for bioimaging".Journal of Materials Chemistry B 4.39(2016):6454-6461.
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