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Influence of bronchial diameter change on the airflow dynamics based on a pressure-controlled ventilation system
Ren, Shuai; Cai, Maolin; Shi, Yan; Xu, Weiqing; Zhang, Xiaohua Douglas
2018-03
Source PublicationINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
ISSN2040-7939
Volume34Issue:3
AbstractBronchial diameter is a key parameter that affects the respiratory treatment of mechanically ventilated patients. In this paper, to reveal the influence of bronchial diameter on the airflow dynamics of pressure-controlled mechanically ventilated patients, a new respiratory system model is presented that combines multigeneration airways with lungs. Furthermore, experiments and simulation studies to verify the model are performed. Finally, through the simulation study, it can be determined that in airway generations 2 to 7, when the diameter is reduced to half of the original value, the maximum air pressure (maximum air pressure in lungs) decreases by nearly 16%, the maximum flow decreases by nearly 30%, and the total airway pressure loss (sum of each generation pressure drop) is more than 5 times the original value. Moreover, in airway generations 8 to 16, with increasing diameter, the maximum air pressure, maximum flow, and total airway pressure loss remain almost constant. When the diameter is reduced to half of the original value, the maximum air pressure decreases by 3%, the maximum flow decreases by nearly 5%, and the total airway pressure loss increases by 200%. The study creates a foundation for improvement in respiratory disease diagnosis and treatment.
Keywordairflow dynamics bronchial diameter change experiment respiratory system model simulation
DOI10.1002/cnm.2929
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Mathematical & Computational Biology ; Mathematics
WOS SubjectEngineering, Biomedical ; Mathematical & Computational Biology ; Mathematics, Interdisciplinary Applications
WOS IDWOS:000426612100004
PublisherWILEY
The Source to ArticleWOS
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Recommended Citation
GB/T 7714
Ren, Shuai,Cai, Maolin,Shi, Yan,et al. Influence of bronchial diameter change on the airflow dynamics based on a pressure-controlled ventilation system[J]. INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING,2018,34(3).
APA Ren, Shuai,Cai, Maolin,Shi, Yan,Xu, Weiqing,&Zhang, Xiaohua Douglas.(2018).Influence of bronchial diameter change on the airflow dynamics based on a pressure-controlled ventilation system.INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING,34(3).
MLA Ren, Shuai,et al."Influence of bronchial diameter change on the airflow dynamics based on a pressure-controlled ventilation system".INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING 34.3(2018).
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