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Gold-nanorods-based gene carriers with the capability of photoacoustic imaging and photothermal therapy
Chen J.2; Liang H.2; Lin L.2; Guo Z.2; Sun P.2; Chen M.1; Tian H.2; Deng M.3; Chen X.2
2016-11-23
Source PublicationACS Applied Materials and Interfaces
ISSN19448252 19448244
Volume8Issue:46Pages:31558-31566
AbstractMultifunctional nanoparticles with high gene transfection activity, low cytotoxicity, photoacoustic imaging ability, and photothermal therapeutic properties were prepared by conjugating low-molecular-weight polyethylenimine onto the surfaces of gold nanorods through the formation of stable S-Au bonded conjugates. Results revealed that the gene transfection efficiency of the prepared polyethylenimine-modified gold nanorods (GNRs-PEI1.8k) was higher and their cytotoxicity was less than those of the commercial reagent PEI25k. GNRs-PEI1.8k could also be potentially used as a photoacoustic and photothermal reagent to evaluate the pharmacokinetics, biodistribution, and antitumor effects of gene/drug nanoparticles. Therefore, GNRs-PEI1.8k can be considered a promising candidate for the clinical diagnosis and treatment of tumors.
Keywordgene therapy gold nanorods multifunctional nanoparticles photoacoustic imaging photothermal therapy
DOI10.1021/acsami.6b10166
URLView the original
Language英語
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Cited Times [WOS]:29   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Universidade de Macau
2.Changchun Institute of Applied Chemistry Chinese Academy of Sciences
3.Northeast Normal University
Recommended Citation
GB/T 7714
Chen J.,Liang H.,Lin L.,et al. Gold-nanorods-based gene carriers with the capability of photoacoustic imaging and photothermal therapy[J]. ACS Applied Materials and Interfaces,2016,8(46):31558-31566.
APA Chen J..,Liang H..,Lin L..,Guo Z..,Sun P..,...&Chen X..(2016).Gold-nanorods-based gene carriers with the capability of photoacoustic imaging and photothermal therapy.ACS Applied Materials and Interfaces,8(46),31558-31566.
MLA Chen J.,et al."Gold-nanorods-based gene carriers with the capability of photoacoustic imaging and photothermal therapy".ACS Applied Materials and Interfaces 8.46(2016):31558-31566.
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