UM
Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer
Song X.2; Xu J.1; Liang C.1; Chao Y.1; Jin Q.1; Wang C.1; Chen M.2; Liu Z.1
2018-10-10
Source PublicationNano Letters
ISSN15306992 15306984
Volume18Issue:10Pages:6360-6368
AbstractThe recent years have witnessed the blooming of cancer immunotherapy, as well as their combinational use together with other existing cancer treatment techniques including radiotherapy. However, hypoxia is one of several causes of the immunosuppressive tumor microenvironment (TME). Herein, we develop an innovative strategy to relieve tumor hypoxia by delivering exogenous HO into tumors and the subsequent catalase-triggered HO decomposition. In our experiment, HO and catalase are separately loaded within stealthy liposomes. After intravenous (iv) preinjection of CAT@liposome, another dose of HO@liposome is injected 4 h later. The sustainably released HO could be decomposed by CAT@liposome, resulting in a long lasting effect in tumor oxygenation enhancement. As the result, the combination treatment by CAT@liposome plus HO@liposome offers remarkably enhanced therapeutic effects in cancer radiotherapy as observed in a mouse tumor model as well as a more clinically relevant patient-derived xenograft tumor model. Moreover, the relieved tumor hypoxia would reverse the immunosuppressive TME to favor antitumor immunities, further enhancing the combined radio-immunotherapy with cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade. This work presents a simple yet effective strategy to promote tumor oxygenation via sequential delivering catalase and exogenous HO into tumors using well-established liposomal carriers, showing great potential for clinical translation in radio-immunotherapy of cancer.
Keywordcheck-point-blockade immunotherapy radiotherapy self-supplied oxygen delivery Tumor hypoxia
DOI10.1021/acs.nanolett.8b02720
URLView the original
Language英語
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Cited Times [WOS]:29   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Soochow University
2.Universidade de Macau
Recommended Citation
GB/T 7714
Song X.,Xu J.,Liang C.,et al. Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer[J]. Nano Letters,2018,18(10):6360-6368.
APA Song X..,Xu J..,Liang C..,Chao Y..,Jin Q..,...&Liu Z..(2018).Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer.Nano Letters,18(10),6360-6368.
MLA Song X.,et al."Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer".Nano Letters 18.10(2018):6360-6368.
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