UM  > Institute of Chinese Medical Sciences
Selective autophagy: The new player in the fight against neurodegenerative diseases?
Wu, Ming-Yue1; Song, Ju-Xian2; Wang, Sheng-Fang1; Cai, Cui-Zan1; Li, Min2; Lu, Jia-Hong1
2018-03
Source PublicationBRAIN RESEARCH BULLETIN
ISSN0361-9230
Volume137Pages:79-90
Abstract

Autophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading organelles, invading pathogens and protein aggregates. Recent studies have revealed an intrinsic connection between selective autophagy and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Given the vital roles of selective autophagy in these neurodegenerative diseases, modulation of this process is emerging as a new therapeutic strategy for neuroprotection. This review introduces the concept of selective autophagy, provides an overview of the pathological connection between selective autophagy and neurodegenerative diseases, and discusses approaches to modulate selective autophagy for therapeutic effects against neurodegenerative diseases.

KeywordSelective Autophagy Neurodegenerative Diesease Aggrephagy Chaperone-mediated Autophagy Mitophagy
DOI10.1016/j.brainresbull.2017.11.009
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000427344300009
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi, Min; Lu, Jia-Hong
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2.Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wu, Ming-Yue,Song, Ju-Xian,Wang, Sheng-Fang,et al. Selective autophagy: The new player in the fight against neurodegenerative diseases?[J]. BRAIN RESEARCH BULLETIN,2018,137:79-90.
APA Wu, Ming-Yue,Song, Ju-Xian,Wang, Sheng-Fang,Cai, Cui-Zan,Li, Min,&Lu, Jia-Hong.(2018).Selective autophagy: The new player in the fight against neurodegenerative diseases?.BRAIN RESEARCH BULLETIN,137,79-90.
MLA Wu, Ming-Yue,et al."Selective autophagy: The new player in the fight against neurodegenerative diseases?".BRAIN RESEARCH BULLETIN 137(2018):79-90.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wu, Ming-Yue]'s Articles
[Song, Ju-Xian]'s Articles
[Wang, Sheng-Fang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wu, Ming-Yue]'s Articles
[Song, Ju-Xian]'s Articles
[Wang, Sheng-Fang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wu, Ming-Yue]'s Articles
[Song, Ju-Xian]'s Articles
[Wang, Sheng-Fang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.