UM
Selective autophagy: The new player in the fight against neurodegenerative diseases?
Wu, Ming-Yue; Song, Ju-Xian; Wang, Sheng-Fang; Cai, Cui-Zan; Li, Min; Lu, Jia-Hong
2018-03
Source PublicationBRAIN RESEARCH BULLETIN
ISSN0361-9230
Volume137Pages:79-90
AbstractAutophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading organelles, invading pathogens and protein aggregates. Recent studies have revealed an intrinsic connection between selective autophagy and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Given the vital roles of selective autophagy in these neurodegenerative diseases, modulation of this process is emerging as a new therapeutic strategy for neuroprotection. This review introduces the concept of selective autophagy, provides an overview of the pathological connection between selective autophagy and neurodegenerative diseases, and discusses approaches to modulate selective autophagy for therapeutic effects against neurodegenerative diseases.
KeywordSelective autophagy Neurodegenerative diesease Aggrephagy Chaperone-mediated autophagy Mitophagy
DOI10.1016/j.brainresbull.2017.11.009
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000427344300009
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
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Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Wu, Ming-Yue,Song, Ju-Xian,Wang, Sheng-Fang,et al. Selective autophagy: The new player in the fight against neurodegenerative diseases?[J]. BRAIN RESEARCH BULLETIN,2018,137:79-90.
APA Wu, Ming-Yue,Song, Ju-Xian,Wang, Sheng-Fang,Cai, Cui-Zan,Li, Min,&Lu, Jia-Hong.(2018).Selective autophagy: The new player in the fight against neurodegenerative diseases?.BRAIN RESEARCH BULLETIN,137,79-90.
MLA Wu, Ming-Yue,et al."Selective autophagy: The new player in the fight against neurodegenerative diseases?".BRAIN RESEARCH BULLETIN 137(2018):79-90.
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