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Roles of Nitric Oxide Synthase Isoforms in Neurogenesis
Chong, Cheong-Meng1; Ai, Nana2; Ke, Minjing1; Tan, Yuan1; Huang, Zhijian1; Li, Yong3; Lu, Jia-Hong1; Ge, Wei2; Su, Huanxing1
2017-04-18
Source PublicationMOLECULAR NEUROBIOLOGY
ISSN0893-7648
Volume55Issue:3Pages:2645-2652
Abstract

Nitric oxide (NO), a free radical gas, acts as a neurotransmitter or neuromodulator in the central nervous system (CNS). It has been widely explored as a mediator of neuroinflammation, neuronal damages, and neurodegeneration at its pathological levels. Recently, increasing evidence suggests that NO plays key roles in mediating adult neurogenesis, the process of neural stem cells (NSCs) to generate newborn neurons for replacing damaged neurons or maintaining the function of the brain. NO synthase (NOS) is a major enzyme catalyzing the generation of NO in the brain. Recent studies indicate that three homologous NOS isoforms are involved in the proliferation of NSCs and neurogenesis. Therefore, the impact of NOS isoforms on NSC functions needs to be elucidated. Here, we summarize the studies on the role of NO and NOS with different isoforms in NSC proliferation and neurogenesis with the focus on introducing action mechanisms involved in the regulation of NSC function. This growing research area provides the new insight into controlling NSC function via regulating NO microenvironment in the brain. It also provides the evidence on targeting NOS for the treatment of brain diseases.

KeywordNitric Oxide Nitric Oxide Synthase Neural Stem Cells Proliferation Neurogenesis
DOIhttp://dx.doi.org/10.1007/s12035-017-0513-7
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000426897800066
PublisherHUMANA PRESS INC
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Faculty of Health Sciences
Corresponding AuthorSu, Huanxing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
2.Faculty of Health Sciences, University of Macau, Macau, China.
3.Department of Biochemistry and Molecular Cell Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chong, Cheong-Meng,Ai, Nana,Ke, Minjing,et al. Roles of Nitric Oxide Synthase Isoforms in Neurogenesis[J]. MOLECULAR NEUROBIOLOGY,2017,55(3):2645-2652.
APA Chong, Cheong-Meng.,Ai, Nana.,Ke, Minjing.,Tan, Yuan.,Huang, Zhijian.,...&Su, Huanxing.(2017).Roles of Nitric Oxide Synthase Isoforms in Neurogenesis.MOLECULAR NEUROBIOLOGY,55(3),2645-2652.
MLA Chong, Cheong-Meng,et al."Roles of Nitric Oxide Synthase Isoforms in Neurogenesis".MOLECULAR NEUROBIOLOGY 55.3(2017):2645-2652.
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