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Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism
Luo, Yumei1; Zhu, Detu2; Xu, Xiangye1; Ge, Lingxia1; Sun, Xiaofang1; Chen, Guokai3,4; Chen, Yaoyong1
2018-03
Source PublicationSTEM CELL RESEARCH
ISSN1873-5061
Volume27Pages:42-45
Abstract

Turner syndrome (TS) with 45,X/46,XY mosaic karyotype is a rare sex chromosome disorder with an occurrence of 0.15% at birth. We report the generation of an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a Chinese adult male with 45,X/46,XY mosaicism. The iPSC line retains the original 45, X/46, XY mosaic karyotype, expresses pluripotency markers and undergoes trilineage differentiation. Therefore, it offers an unprecedented cellular model to investigate the profound symptoms like infertility of TS in the male, and serve as a useful tool to develop therapies for the disease. (c) 2018 The Authors. Published by Elsevier B.V.

DOIhttps://doi.org/10.1016/j.scr.2018.01.003
URLView the original
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Biotechnology & Applied Microbiology
WOS SubjectCell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology
WOS IDWOS:000427533700010
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChen, Yaoyong
Affiliation1.Key Laboratory for Major Obstetric Diseases of Guangdong Province; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital ofGuangzhou Medical University, Guangzhou 510150, China
2.Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
3.Faculty of Health Sciences, University of Macau, Macau 999078, China
4.National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
Recommended Citation
GB/T 7714
Luo, Yumei,Zhu, Detu,Xu, Xiangye,et al. Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism[J]. STEM CELL RESEARCH,2018,27:42-45.
APA Luo, Yumei.,Zhu, Detu.,Xu, Xiangye.,Ge, Lingxia.,Sun, Xiaofang.,...&Chen, Yaoyong.(2018).Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism.STEM CELL RESEARCH,27,42-45.
MLA Luo, Yumei,et al."Generation of an induced pluripotent stem cell line from an adult male with 45,X/46,XY mosaicism".STEM CELL RESEARCH 27(2018):42-45.
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