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Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder: a multicenter study
Xiao, Le1; Feng, Lei1; Zhu, Xue-quan1; Feng, Yuan1; Wu, Wen-yuan2; Ungvari, Gabor S.3; Ng, Chee H.4; Xiang, Yu-Tao5; Wang, Gang1
2018-03
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
Volume261Pages:547-553
Abstract

This study compared residual depressive and somatic symptoms and functional impairment between remitted and partially remitted patients with major depressive disorder (MDD), and explored the associations of functioning with demographic and clinical characteristics including residual depressive symptoms. Altogether, 1503 outpatients with MDD formed the study sample. Residual symptoms and psychosocial functioning were measured using standardized instruments. Approximately half (51.2%) of the patients who responded to antidepressant treatment achieved remission ('remitters'), while the rest who responded to treatment achieved only partial remission ('non-remitters'). Residual mood symptoms in remitters included sleep disturbances (66.6%), fatigue (32.3%), decreased concentration (31.3%), appetite/weight disturbances (28.8%), psychomotor changes (23.2%), sad mood (21.9%) and loss of interest (21.1%) measured by the Quick Inventory of Depressive Symptomatology-Self-Report. Residual somatic symptoms included headache (31.9%), intestinal complaints (31.3%), heart pounding/racing (26.3%), gastric complaints (22.3%), dizziness (22.2%) and stomach pain (20.6%) measured by the Patient Health Questionnaire-15. Such residual symptoms were even more frequent in the 'non-remitters' group. Residual symptoms of fatigue, psychomotor changes, sleep disturbance and appetite/weight disturbance contributed to impairment of all functional domains. Given the negative impact of residual symptoms on psychosocial functioning, more attention needs to be paid to the assessment and treatment of residual depressive symptoms.

KeywordMajor Depressive Disorder Residual Symptoms Functioning Remission Treatment Response
DOIhttps://doi.org/10.1016/j.psychres.2018.01.020
URLView the original
Indexed BySCI ; SSCI ; SSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000426222600084
PublisherELSEVIER IRELAND LTD
The Source to ArticleWOS
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiang, Yu-Tao; Wang, Gang
Affiliation1.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Anding Hospital, Capital Medical University, Beijing, China
2.Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China
3.The University of Notre Dame Australia/Graylands Hospital, Perth, Australia
4.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
5.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Xiao, Le,Feng, Lei,Zhu, Xue-quan,et al. Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder: a multicenter study[J]. PSYCHIATRY RESEARCH,2018,261:547-553.
APA Xiao, Le.,Feng, Lei.,Zhu, Xue-quan.,Feng, Yuan.,Wu, Wen-yuan.,...&Wang, Gang.(2018).Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder: a multicenter study.PSYCHIATRY RESEARCH,261,547-553.
MLA Xiao, Le,et al."Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder: a multicenter study".PSYCHIATRY RESEARCH 261(2018):547-553.
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