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Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells
Wang, Zhenzhen1; Wang, Chunming2; Abudukeremu, Ayipaxia1; Rui, Xiaying1; Liu, Shang1; Zhang, Xiaoyi3; Zhang, Min1; Zhang, Junfeng1; Dong, Lei1
2018-03
Source PublicationADVANCED SCIENCE
ISSN2198-3844
Volume5Issue:3
Abstract

The insufficient number of cells suitable for transplantation is a long-standing problem to cell-based therapies aimed at tissue regeneration. Xenogeneic cancer cells (XCC) may be an alternative source of therapeutic cells, but their transplantation risks both immune rejection and unwanted spreading. In this study, a strategy to facilitate XCC transplantation is reported and their spreading in vivo is confined by constructing an engineering matrix that mimics the characteristics of tumor microenvironment. The data show that this matrix, a tumor homogenate-containing hydrogel (THAG), successfully creates an immunosuppressive enclave after transplantation into immunocompetent mice. XCC of different species and tissue origins seeded into THAG survive well, integrated with the host and developed the intrinsic morphology of the native tissue, without being eliminated or spreading out of the enclave. Most strikingly, immortalized human hepatocyte cells and rat beta-cells loaded into THAG exert the physiological functions of the human liver and rat pancreas islets, respectively, in the mouse body. This study demonstrates a novel and feasible approach to harness the unique features of tumor development for tissue transplantation and regenerative medicine.

KeywordIntrinsic Morphology Physiological Functions Regenerative Medicine Tumor Microenvironment-mimetic Niche Xenogeneic Cancer Cells
DOI10.1002/advs.201700666
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000428310500027
PublisherWILEY
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Chunming; Zhang, Junfeng; Dong, Lei
Affiliation1.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR
3.Department of Chemistry, Emory University, Atlanta, GA, USA
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang, Zhenzhen,Wang, Chunming,Abudukeremu, Ayipaxia,et al. Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells[J]. ADVANCED SCIENCE,2018,5(3).
APA Wang, Zhenzhen.,Wang, Chunming.,Abudukeremu, Ayipaxia.,Rui, Xiaying.,Liu, Shang.,...&Dong, Lei.(2018).Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells.ADVANCED SCIENCE,5(3).
MLA Wang, Zhenzhen,et al."Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells".ADVANCED SCIENCE 5.3(2018).
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