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The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma
Huang, Yide1,2; Zhang, Yafei1; Ge, Lilin2,3; Lin, Yao1; Kwok, Hang Fai2
2018-03
Source PublicationCANCERS
ISSN2072-6694
Volume10Issue:3Pages:82
Abstract

The protein tyrosine phosphatase (PTP) family is involved in multiple cellular functions and plays an important role in various pathological and physiological processes. In many chronic diseases, for example cancer, PTP is a potential therapeutic target for cancer treatment. In the last two decades, dozens of PTP inhibitors which specifically target individual PTP molecules were developed as therapeutic agents. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and is the second most lethal cancer worldwide due to a lack of effective therapies. Recent studies have unveiled both oncogenic and tumor suppressive functions of PTP in HCC. Here, we review the current knowledge on the involvement of PTP in HCC and further discuss the possibility of targeting PTP in HCC.

KeywordProtein-tyrosine Phosphatase Inhibitors Hepatocellular Carcinoma Signaling Pathways Therapeutic Targets
DOIhttps://doi.org/10.3390/cancers10030082
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000428776200024
PublisherMDPI
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLin, Yao; Kwok, Hang Fai
Affiliation1.Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China
2.Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau, China
3.Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Huang, Yide,Zhang, Yafei,Ge, Lilin,et al. The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma[J]. CANCERS,2018,10(3):82.
APA Huang, Yide,Zhang, Yafei,Ge, Lilin,Lin, Yao,&Kwok, Hang Fai.(2018).The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma.CANCERS,10(3),82.
MLA Huang, Yide,et al."The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma".CANCERS 10.3(2018):82.
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