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Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries
Xie, Ruiqiang1; Zhang, Xiaohua Douglas1; Zhao, Qi1; Peng, Bo2,3; Zheng, Jun4
2018-03-14
Source PublicationEMERGING MICROBES & INFECTIONS
ISSN2222-1751
Volume7
Abstract

Acinetobacter baumannii is one of the most challenging nosocomial pathogens due to the emergence and widespread of antibiotic resistance. We aimed to provide the first analysis of global prevalence of antibiotic resistance in A. baumannii infections, by synthesizing data and knowledge through a systematic review. We searched studies reporting antibiotic resistance in A. baumannii infections using the Medline, Embase, Web of Science, and Cochrane databases from January 2000 to December 2016. Studies were eligible if they investigated and reported antibiotic resistance in A. baumannii infections with inpatients or outpatients in hospital. Our investigation showed a high prevalence of resistance to the common prescribed antibiotics in A. baumannii infections in both OECD (Organization for Economic Co-operation and Development) and non-OECD countries. Strikingly, though OECD countries have substantially lower pooled prevalence of resistance compared to non-OECD countries based on the data during 2006-2016, a further investigation in a time scale disclosed a faster increase in OECD countries during the past 11 years, and currently both of them have a comparable prevalence of resistance (2011-2016). Tigecycline and colistin are still active but their resistances are expected to become common if the preventative measures are not taken. Antibiotic resistance in A. baumannii infection developed fast and is a crisis for both OECD and non-OECD countries. A "post-antibiotic era" for A. baumannii infection is expected in the next 10-20 years without immediate actions from pharmaceutical companies and governments.

DOI10.1038/s41426-018-0038-9
URLView the original
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Microbiology
WOS SubjectImmunology ; Microbiology
WOS IDWOS:000427439000007
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZheng, Jun
Affiliation1.Faculty of Health Sciences, University of Macau, Macau SAR, China.
2.State Key Laboratory of Bio-Control, School of Life Sciences, Sun Yat-sen University, 510006, Guangzhou, China.
3.Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, 266071, Qingdao, China.
4.Faculty of Health Sciences, University of Macau, Macau SAR, China.
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Xie, Ruiqiang,Zhang, Xiaohua Douglas,Zhao, Qi,et al. Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries[J]. EMERGING MICROBES & INFECTIONS,2018,7.
APA Xie, Ruiqiang,Zhang, Xiaohua Douglas,Zhao, Qi,Peng, Bo,&Zheng, Jun.(2018).Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries.EMERGING MICROBES & INFECTIONS,7.
MLA Xie, Ruiqiang,et al."Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries".EMERGING MICROBES & INFECTIONS 7(2018).
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