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Mindfulness-based interventions for major depressive disorder: A comprehensive meta-analysis of randomized controlled trials
Yuan-Yuan Wang1; Xiao-Hong Li2; Wei Zheng3; Zi-Yan Xu4; Chee H. Ng5; Gabor S. Ungvari6; Zhen Yuan1; Yu-Tao Xiang7
2018-03-15
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Volume229Pages:429-436
Abstract

Background: This is a meta-analysis of randomized controlled trials (RCTs) of mindfulness-based interventions (MBIs) for a current episode of major depressive disorder.

Methods: Both English (PubMed, PsycINFO, Embase, and Cochrane Library databases) and Chinese (WanFang and CNKI) databases were systematically and independently searched. Standardized mean differences (SMDs) and risk ratio (RR) +/- their 95% confidence intervals (CIs) based on the random effects model were calculated.

Results: A total of 11 RCTs with 12 treatment arms (n = 764; MBIs = 363; and control group = 401) were identified and analyzed. Compared to the control group, MDD subjects receiving MBIs showed significant reduction in depressive symptoms (n = 722; SMD:-0.59, 95% CI:-1.01 to-0.17, I-2 = 85%, p = 0.006) at post-MBIs assessment, but the significance disappeared by the end of posttreatment follow-up. Subgroup analyses revealed that positive benefits of MBIs was associated with studies that had treatment as usual (TAU) control group, Chinese participants, open label design, no gender predominance, subjects younger than 44.4 years, and Jadad score >= 3, other illness phase and MBIs as augmentation group.

Conclusion: This meta-analysis found that MBIs was associated with reduction of depression severity immediately after MBIs but not at follow up endpoint. Further, the positive effects of MBIs were mainly driven by outlying studies. Higher quality of RCTs with larger samples and longer study duration are needed to confirm the findings.

KeywordMajor Depressive Disorder Mindfulness-based Interventions Meta-analysis
DOIhttp://doi.org/10.1016/j.jad.2017.12.093
URLView the original
Indexed BySCI ; SSCI ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000424335600058
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF COLLABORATIVE INNOVATION
Faculty of Health Sciences
Corresponding AuthorYu-Tao Xiang
Affiliation1.Faculty of Health Sciences, University of Macau, Macao SAR, China.
2.The National Clinical Research Center for Mental Disorders, China &Center of Depression, Beijing Institute for Brain Disorders & Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China
3.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
4.Department of Psychiatry II, University of Ulm and BKH Günzburg, Germany
5.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
6.University of Notre Dame Australia / Graylands Hospital, Perth, Australia
7.Faculty of Health Sciences, University of Macau, Macao SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yuan-Yuan Wang,Xiao-Hong Li,Wei Zheng,et al. Mindfulness-based interventions for major depressive disorder: A comprehensive meta-analysis of randomized controlled trials[J]. JOURNAL OF AFFECTIVE DISORDERS,2018,229:429-436.
APA Yuan-Yuan Wang.,Xiao-Hong Li.,Wei Zheng.,Zi-Yan Xu.,Chee H. Ng.,...&Yu-Tao Xiang.(2018).Mindfulness-based interventions for major depressive disorder: A comprehensive meta-analysis of randomized controlled trials.JOURNAL OF AFFECTIVE DISORDERS,229,429-436.
MLA Yuan-Yuan Wang,et al."Mindfulness-based interventions for major depressive disorder: A comprehensive meta-analysis of randomized controlled trials".JOURNAL OF AFFECTIVE DISORDERS 229(2018):429-436.
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