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Highly Biocompatible Chlorin e6-Loaded Chitosan Nanoparticles for Improved Photodynamic Cancer Therapy
Ding, Yuan-Fu1,2; Li, Shengke2; Liang, Lijun1; Huang, Qiaoxian2; Yuwen, Lihui1; Yang, Wenjing1; Wang, Ruibing2; Wang, Lian-Hui1
2018-03-28
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:12Pages:9980-9987
Abstract

The photosensitizer Chlorin e6 (Ce6) has been frequently employed for photodynamic therapy (PDT) of cancer; however, its nonspecific toxicity has limited its clinical applications. In this study, we prepared chitosan nanoparticles (CNPs), with a mean diameter of approximately 130 nm, by a nonsolvent-aided counterion complexation method in an aqueous solution, into which Ce6 could be physically entrapped during the preparation process. These CNPs and Ce6-loaded CNPs (CNPs-Ce6) were fully characterized by UV-vis, photoluminescence, and Fourier transform infrared spectroscopic analysis, as well as dynamic light scattering and transmission electron microscopy measurements. More importantly, the biocompatibility of the otherwise toxic Ce6 was significantly improved upon its loading into the CNPs, as demonstrated by both confocal laser scanning microscopy analysis and 3-(4,5-dimethylthiazo1-2-y1)-2,S-diphenyltetrazolium bromide (MTT) assays. Furthermore, the PDT efficiency of Ce6-loaded CNPs was dramatically enhanced, in comparison with that of the free Ce6, as shown by both MTT and flow cytometry assays. This discovery provides a novel strategy for improving the biocompatibility and therapeutic efficacy of PDT agents by using a natural, biocompatible polysaccharide carrier.

KeywordBiocompatibility Cell Imaging Drug Delivery Systems Natural Chitosan Photodynamic Therapy
DOIhttp://doi.org/10.1021/acsami.8b01522
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000428972700012
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Ruibing; Wang, Lian-Hui
Affiliation1.Key Laboratory for Organic Electronics and Information Displays, Jiangsu Key Laboratory of Biosensors, Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ding, Yuan-Fu,Li, Shengke,Liang, Lijun,et al. Highly Biocompatible Chlorin e6-Loaded Chitosan Nanoparticles for Improved Photodynamic Cancer Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(12):9980-9987.
APA Ding, Yuan-Fu.,Li, Shengke.,Liang, Lijun.,Huang, Qiaoxian.,Yuwen, Lihui.,...&Wang, Lian-Hui.(2018).Highly Biocompatible Chlorin e6-Loaded Chitosan Nanoparticles for Improved Photodynamic Cancer Therapy.ACS APPLIED MATERIALS & INTERFACES,10(12),9980-9987.
MLA Ding, Yuan-Fu,et al."Highly Biocompatible Chlorin e6-Loaded Chitosan Nanoparticles for Improved Photodynamic Cancer Therapy".ACS APPLIED MATERIALS & INTERFACES 10.12(2018):9980-9987.
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