UM
NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth
Zha X.1; Hu Z.4; Ji S.1; Jin F.1; Jiang K.1; Li C.4; Zhao P.1; Tu Z.1; Chen X.1; Di L.1; Zhou H.1; Zhang H.4
2015-04-01
Source PublicationCancer Letters
ISSN18727980 03043835
Volume359Issue:1Pages:97-106
AbstractAccumulating evidence indicates that mammalian target of rapamycin (mTOR) exerts a crucial role in aerobic glycolysis and tumorigenesis, but the underlying mechanisms remain largely obscure. Results from Tsc1- or Tsc2-null mouse embryonic fibroblasts (MEFs) and human cancer cell lines consistently indicate that the expression of glucose transporter 3 (Glut3) is dramatically up-regulated by mTOR. The rapamycin-sensitive mTOR complex 1 (mTORC1), but not the rapamycin-insensitive mTOR complex 2 (mTORC2), was involved in the regulation of Glut3 expression. Moreover, mTORC1 enhances Glut3 expression through the activation of the IKK/NFκB pathway. Depletion of Glut3 led to the suppression of aerobic glycolysis, the inhibition of cell proliferation and colony formation, and the attenuation of the tumorigenic potential of the cells with aberrantly hyper-activated mTORC1 signaling in nude mice. We conclude that Glut3 is a downstream target of mTORC1, and it is critical for oncogenic mTORC1-mediated aerobic glycolysis and tumorigenesis. Hence Glut3 may be a potential target for therapy against cancers caused by the aberrantly activated mTORC1 signaling.
KeywordAerobic glycolysis Glut3 MTOR NFκB Tumorigenesis
DOI10.1016/j.canlet.2015.01.001
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Anhui Medical University
2.Universidade de Macau
3.Beijing University of Chinese Medicine
4.Institute of Basic Medical Sciences Chinese Academy of Medical Sciences
Recommended Citation
GB/T 7714
Zha X.,Hu Z.,Ji S.,et al. NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth[J]. Cancer Letters,2015,359(1):97-106.
APA Zha X..,Hu Z..,Ji S..,Jin F..,Jiang K..,...&Zhang H..(2015).NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth.Cancer Letters,359(1),97-106.
MLA Zha X.,et al."NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth".Cancer Letters 359.1(2015):97-106.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zha X.]'s Articles
[Hu Z.]'s Articles
[Ji S.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zha X.]'s Articles
[Hu Z.]'s Articles
[Ji S.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zha X.]'s Articles
[Hu Z.]'s Articles
[Ji S.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.