UM  > 健康科學學院
Integrated analysis reveals tubal- and ovarian-originated serous ovarian cancer and predicts differential therapeutic responses
Hao D.; Li J.; Jia S.; Meng Y.; Zhang C.; Wang L.; Di L.-J.
2017-12-01
Source PublicationClinical Cancer Research
ISSN15573265 10780432
Volume23Issue:23Pages:7400-7411
Abstract

Purpose: The relative importance of fallopian tube (FT) compared with ovarian surface epithelium (OSE) in the genesis of serous type of ovarian cancer (SOC) is still unsettled. Here, we followed an integrated approach to study the tissue origin of SOC, as well as its association with clinical outcome and response to therapeutic drugs. Experimental Design: A collection of transcriptome data of 80 FTs, 89 OSEs, and 2,668 SOCs was systematically analyzed to determine the characteristic of FT-like and OSE-like tumors. A molecular signature was developed for identifying tissue origin of SOC and then was used to reevaluate the prognostic genes and therapeutic biomarkers of SOC of different tissue origins. IHC staining of tissue array and functional experiments on a panel of ovarian cancer cell lines were used to further validate the key findings. Results: The expression patterns of tissue-specific genes, prognostic genes, and molecular markers all support a dualistic tissue origin of SOC, from either FT or OSE. A molecular signature was established to identify the tissue identity of SOCs. Surprisingly, the signature showed a strong association with overall survival (OSE-like vs. FT-like, HR = 4.16; 95% CI, 2.67–6.48; P < 10-). The pharmacogenomic approach revealed AXL to be a therapeutic target of the aggressive OSE-derived SOC. Conclusions: SOC has two subtypes originated from either FT or OSE, which show different clinical and pathologic features.

DOI10.1158/1078-0432.CCR-17-0638
URLView the original
Indexed BySCI
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000416908200026
Fulltext Access
Citation statistics
Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniversidade de Macau
Recommended Citation
GB/T 7714
Hao D.,Li J.,Jia S.,et al. Integrated analysis reveals tubal- and ovarian-originated serous ovarian cancer and predicts differential therapeutic responses[J]. Clinical Cancer Research,2017,23(23):7400-7411.
APA Hao D..,Li J..,Jia S..,Meng Y..,Zhang C..,...&Di L.-J..(2017).Integrated analysis reveals tubal- and ovarian-originated serous ovarian cancer and predicts differential therapeutic responses.Clinical Cancer Research,23(23),7400-7411.
MLA Hao D.,et al."Integrated analysis reveals tubal- and ovarian-originated serous ovarian cancer and predicts differential therapeutic responses".Clinical Cancer Research 23.23(2017):7400-7411.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hao D.]'s Articles
[Li J.]'s Articles
[Jia S.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hao D.]'s Articles
[Li J.]'s Articles
[Jia S.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hao D.]'s Articles
[Li J.]'s Articles
[Jia S.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.