UM  > 健康科學學院
Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemosensitivity
Hao D.1; Liu J.1; Chen M.2; Li J.1; Wang L.1; Li X.2; Zhao Q.1; Di L.-J.1
2018-08-01
Source PublicationClinical Cancer Research
ISSN15573265 10780432
Volume24Issue:15Pages:3560-3571
Abstract

Purpose: Ovarian cancer is one of the first human cancers for which in situ immune response was reported to be important for the clinical outcome. To elucidate the mechanistic relationship between immune repertoire and cancer genotype in ovarian cancer, the development of a well-defined immune score for ovarian cancer is required. Experimental Design: From a collection of 2,203 patient samples of advanced ovarian cancer from public available resources, we evaluated the prognostic values for a compendium of immune marker genes and proposed an immune score. The relationships between immune score, tumor-infiltrating immune cells, cancer genotypes, and their impact on patient outcome were characterized. Results: Loss of chemokine and IFNg pathway genes is frequent in ovarian cancer and is significantly associated with low immune score and poor outcome. Chemotherapy can increase the immune score of tumors by inducing the expression of IFNg inducible chemokines. High immune score is significantly associated with BRCA1/2 mutation status and the response to chemotherapy. Multivariate analysis revealed that immune score is a strong predictor of patient survival and the response to immunotherapy. Conclusions: Our results reveal the drivers of the immune repertoire of advanced ovarian cancer and demonstrate the importance of immune score as an independent prognostic signature and a potent indicator of intratumoral immune status. Clin Cancer Res; 24(15); 3560-71. 2018 AACR.

DOI10.1158/1078-0432.CCR-17-3862
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000440600200012
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Universidade de Macau
2.Harbin Medical University
Recommended Citation
GB/T 7714
Hao D.,Liu J.,Chen M.,et al. Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemosensitivity[J]. Clinical Cancer Research,2018,24(15):3560-3571.
APA Hao D..,Liu J..,Chen M..,Li J..,Wang L..,...&Di L.-J..(2018).Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemosensitivity.Clinical Cancer Research,24(15),3560-3571.
MLA Hao D.,et al."Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemosensitivity".Clinical Cancer Research 24.15(2018):3560-3571.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hao D.]'s Articles
[Liu J.]'s Articles
[Chen M.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hao D.]'s Articles
[Liu J.]'s Articles
[Chen M.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hao D.]'s Articles
[Liu J.]'s Articles
[Chen M.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.