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Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment
Lin Y.2; Li X.-Y.2; Willis A.L.2; Liu C.1; Chen G.1; Weiss S.J.2
2014-01-09
Source PublicationNature Communications
ISSN20411723
Volume5
Abstract

Embryonic stem cells (ESCs) exhibit the dual properties of self-renewal and pluripotency as well as the ability to undergo differentiation that gives rise to all three germ layers. Wnt family members can both promote ESC maintenance and trigger differentiation while also controlling the expression of Snail1, a zinc-finger transcriptional repressor. Snail1 has been linked to events ranging from cell cycle regulation and cell survival to epithelial-mesenchymal transition (EMT) and gastrulation, but its role in self-renewal, pluripotency or lineage commitment in ESCs remains undefined. Here we demonstrate using isogenic pairs of conditional knockout mouse ESCs, that Snail1 exerts Wnt-and EMT independent control over the stem cell transcriptome without affecting self-renewal or pluripotency-associated functions. By contrast, during ESC differentiation, an endogenous Wnt-mediated burst in Snail1 expression regulates neuroectodermal fate while playing a required role in epiblast stem cell exit and the consequent lineage fate decisions that define mesoderm commitment. © 2014 Macmillan Publishers Limited.

DOI10.1038/ncomms4070
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000331084200012
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Citation statistics
Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.National Heart, Lung, and Blood Institute
2.University of Michigan Medical School
Recommended Citation
GB/T 7714
Lin Y.,Li X.-Y.,Willis A.L.,et al. Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment[J]. Nature Communications,2014,5.
APA Lin Y.,Li X.-Y.,Willis A.L.,Liu C.,Chen G.,&Weiss S.J..(2014).Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment.Nature Communications,5.
MLA Lin Y.,et al."Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment".Nature Communications 5(2014).
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