UM
Insulin-Like Growth Factor 1 Prevents Neuronal Cell Death Induced by Corticosterone Through Activation of the PI3K/Akt Pathway
Nitta A.; Zheng W.-H.; Quirion R.
2004-04-01
Source PublicationJournal of Neuroscience Research
ISSN03604012
Volume76Issue:1Pages:98-103
AbstractCorticosterone (CORT) is well known to induce neuronal damage in various brain regions including the hippocampus, but the precise mechanism(s) of action underlying these effects has yet to be fully established. Insulin-like growth factor-1 (IGF-1) is a trophic factor promoting cell survival by the activation of the phosphatidylinositide 3-kinase (PI3K)/Akt kinase pathway. We report that IGF-1 prevents neuronal cell death induced by CORT, likely via the stimulation of the PI3K/Akt pathway in primary hippocampal cultured neurons. CORT induced neuronal cell death at a minimal concentration of 50 nM. IGF-1 (10 nM) prevented cell death induced by CORT under serum-free conditions. The neuroprotective effect of IGF-1 was accompanied by reversal of the Akt pathway inhibition induced by CORT. The PI3 kinase inhibitor, LY29004, inhibited the neuroprotective effect of IGF-1 whereas the MEK (MAPK kinase) inhibitor PD98059, an upstream blocker of mitogen-activated protein (MAP) kinase, had no effect. These results suggest that IGF-1 can prevent neuronal cell death induced by CORT in hippocampal neurons by modulating the activity of the PI3K/Akt pathway. © 2004 Wiley-Liss, Inc.
KeywordCell culture Corticosterone IGF-1 LY29004 PD98059 Rats
DOI10.1002/jnr.20057
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:41   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationDouglas Hospital Research Center
Recommended Citation
GB/T 7714
Nitta A.,Zheng W.-H.,Quirion R.. Insulin-Like Growth Factor 1 Prevents Neuronal Cell Death Induced by Corticosterone Through Activation of the PI3K/Akt Pathway[J]. Journal of Neuroscience Research,2004,76(1):98-103.
APA Nitta A.,Zheng W.-H.,&Quirion R..(2004).Insulin-Like Growth Factor 1 Prevents Neuronal Cell Death Induced by Corticosterone Through Activation of the PI3K/Akt Pathway.Journal of Neuroscience Research,76(1),98-103.
MLA Nitta A.,et al."Insulin-Like Growth Factor 1 Prevents Neuronal Cell Death Induced by Corticosterone Through Activation of the PI3K/Akt Pathway".Journal of Neuroscience Research 76.1(2004):98-103.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Nitta A.]'s Articles
[Zheng W.-H.]'s Articles
[Quirion R.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Nitta A.]'s Articles
[Zheng W.-H.]'s Articles
[Quirion R.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Nitta A.]'s Articles
[Zheng W.-H.]'s Articles
[Quirion R.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.