UM
Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells
Kamato D.; Rostam M.A.; Piva T.J.; Babaahmadi Rezaei H.; Getachew R.; Thach L.; Bernard R.; Zheng W.; Little P.J.; Osman N.
2014-12-01
Source PublicationThe Journal of pharmacy and pharmacology
ISSN20427158
Volume66Issue:12Pages:1722-1733
AbstractOBJECTIVES: Transforming growth factor (TGF)-β regulates the function of vascular endothelial cells and may be involved in endothelial dysfunction. The canonical TGF-β pathway involves TGF-β receptor-mediated carboxy-terminal phosphorylation of Smad2; however, TGF-β signalling also activates numerous serine/threonine kinases that phosphorylate Smad2 in its linker region. The expression of phosphorylated Smad linker proteins were determined following TGF-β stimulation in the absence and presence of different serine/threonine kinase inhibitors in vascular endothelial cells.
Keywordcell signalling serine/threonine kinase Smad linker region Smads transforming growth factor-β
DOI10.1111/jphp.12298
URLView the original
Language英語
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Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationRMIT University
Recommended Citation
GB/T 7714
Kamato D.,Rostam M.A.,Piva T.J.,et al. Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells[J]. The Journal of pharmacy and pharmacology,2014,66(12):1722-1733.
APA Kamato D..,Rostam M.A..,Piva T.J..,Babaahmadi Rezaei H..,Getachew R..,...&Osman N..(2014).Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells.The Journal of pharmacy and pharmacology,66(12),1722-1733.
MLA Kamato D.,et al."Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells".The Journal of pharmacy and pharmacology 66.12(2014):1722-1733.
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