Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells

doi:10.1111/jphp.12298

	Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells
	Kamato D.; Rostam M.A.; Piva T.J.; Babaahmadi Rezaei H.; Getachew R.; Thach L.; Bernard R.; Zheng W.; Little P.J.; Osman N.
	2014-12-01
Source Publication	The Journal of pharmacy and pharmacology
ISSN	20427158
Volume	66 Issue:12 Pages:1722-1733
Abstract	OBJECTIVES: Transforming growth factor (TGF)-β regulates the function of vascular endothelial cells and may be involved in endothelial dysfunction. The canonical TGF-β pathway involves TGF-β receptor-mediated carboxy-terminal phosphorylation of Smad2; however, TGF-β signalling also activates numerous serine/threonine kinases that phosphorylate Smad2 in its linker region. The expression of phosphorylated Smad linker proteins were determined following TGF-β stimulation in the absence and presence of different serine/threonine kinase inhibitors in vascular endothelial cells.
Keyword	cell signalling serine/threonine kinase Smad linker region Smads transforming growth factor-β
DOI	10.1111/jphp.12298
URL	View the original
Language	英語
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics	Cited Times [WOS]:20 [WOS Record] [Related Records in WOS]
Document Type	Journal article
Collection	University of Macau
Affiliation	RMIT University
Recommended Citation GB/T 7714	Kamato D.,Rostam M.A.,Piva T.J.,et al. Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells[J]. The Journal of pharmacy and pharmacology,2014,66(12):1722-1733.
APA	Kamato D..,Rostam M.A..,Piva T.J..,Babaahmadi Rezaei H..,Getachew R..,...&Osman N..(2014).Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells.The Journal of pharmacy and pharmacology,66(12),1722-1733.
MLA	Kamato D.,et al."Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells".The Journal of pharmacy and pharmacology 66.12(2014):1722-1733.

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