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Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease
Rostam M.A.1; Piva T.J.1; Rezaei H.B.1; Kamato D.1; Little P.J.1; Zheng W.2; Osman N.1
2015
Source PublicationClinical and Experimental Pharmacology and Physiology
ISSN14401681 03051870
Volume42Issue:2Pages:117-124
AbstractPeptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are three different classes of PPIases and increasing interest in the development of specific PPIase inhibitors. Cyclosporine A, FK506, rapamycin and juglone are known PPIase inhibitors. Herein, we review recent advances in elucidating the role and regulation of the PPIase family in vascular disease. We focus on peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1), an important member of the PPIase family that plays a role in cell cycle progression, gene expression, cell signalling and cell proliferation. In addition, Pin1 may be involved in atherosclerosis. The unique role of Pin1 as a molecular switch that impacts on multiple downstream pathways necessitates the evaluation of a highly specific Pin1 inhibitor to aid in potential therapeutic drug discovery.
KeywordAtherosclerosis Cardiovascular disease Peptidyl-prolyl isomerase Pin1
DOI10.1111/1440-1681.12335
URLView the original
Language英語
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.RMIT University
2.Zhongshan Ophthalmic Center
3.Monash University
4.International Islamic University Malaysia
5.Tehran University of Medical Sciences
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Rostam M.A.,Piva T.J.,Rezaei H.B.,et al. Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease[J]. Clinical and Experimental Pharmacology and Physiology,2015,42(2):117-124.
APA Rostam M.A..,Piva T.J..,Rezaei H.B..,Kamato D..,Little P.J..,...&Osman N..(2015).Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease.Clinical and Experimental Pharmacology and Physiology,42(2),117-124.
MLA Rostam M.A.,et al."Peptidyl-prolyl isomerases: Functionality and potential therapeutic targets in cardiovascular disease".Clinical and Experimental Pharmacology and Physiology 42.2(2015):117-124.
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