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Chemically bonding of amantadine with gardenamide A enhances the neuroprotective effects against corticosterone-induced insults in PC12 cells
Zhao J.4; Peng L.4; Zheng W.3; Wang R.2; Zhang L.4; Yang J.4; Chen H.4
2015-09-21
Source PublicationInternational Journal of Molecular Sciences
ISSN14220067 16616596
Volume16Issue:9Pages:22795-22810
AbstractTwo amantadine (ATD)-gardenamide A (GA) ligands have been designed and synthesized. The bonding of ATD with GA through a methylene carbonyl brigde (L1) enhances the neuroprotective effect against corticosterone (CORT)-induced impairments in PC12 cells; while the bonding through a succinyl brigde (L2) does not. L1 reduces the level of reactive oxygen species (ROS) and cell apoptosis generated by CORT. It restores CORT-changed cell morphology to a state that is closed to normal PC12 cells. One mechanism of L1 to attenuate CORT-induced cell apoptosis is through the adjustment of both caspase-3 and Bcl-2 proteins. Like GA, both nNOS and eNOS might be involved in the neuroprotective mechanism of L1. All the evidences suggest that L1 may be a potential agent to treat depression.
KeywordAmantadine eNOS Gardenamide A Neuroprotection NMDA nNOS
DOI10.3390/ijms160922795
URLView the original
Language英語
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research
2.Jiangxi University of Traditional Chinese Medicine
3.Universidade de Macau
4.Jinan University
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GB/T 7714
Zhao J.,Peng L.,Zheng W.,et al. Chemically bonding of amantadine with gardenamide A enhances the neuroprotective effects against corticosterone-induced insults in PC12 cells[J]. International Journal of Molecular Sciences,2015,16(9):22795-22810.
APA Zhao J..,Peng L..,Zheng W..,Wang R..,Zhang L..,...&Chen H..(2015).Chemically bonding of amantadine with gardenamide A enhances the neuroprotective effects against corticosterone-induced insults in PC12 cells.International Journal of Molecular Sciences,16(9),22795-22810.
MLA Zhao J.,et al."Chemically bonding of amantadine with gardenamide A enhances the neuroprotective effects against corticosterone-induced insults in PC12 cells".International Journal of Molecular Sciences 16.9(2015):22795-22810.
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