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Meta-analysis of serum insulin-like growth factor 1 in Alzheimer's disease
Ostrowski P.P.2; Barszczyk A.2; Forstenpointner J.2; Zheng W.1; Feng Z.-P.2
2016-05-01
Source PublicationPLoS ONE
ISSN19326203
Volume11Issue:5
AbstractInsulin-like growth factor 1 (IGF-1) serum levels have been reported to be altered in Alzheimer's disease patients, and it was suggested that the changes in IGF-1 serum level may play a role in disease pathology and progression. However, this notion remained controversial due to conflicting findings. We conducted a meta-analysis to determine the relationship between IGF-1 serum levels and Alzheimer's disease. We searched the databases PUBMED, Ovid SP, and Cochrane library for relevant studies. The primary data analyzed was serum IGF-1 from Alzheimer's disease subjects and controls. Pooled weighted mean difference using a random effects model was used to determine the relationship between serum levels and disease state. Nine studies were included in the meta-analysis compromising a total of 1639 subjects. The pooled weighted mean difference was -2.27ng/ml (95% CI: [-22.221, 17.66]) with a P value of 0.82. Thus our finding did not show clear relationship between low IGF-1 and Alzheimer's disease subjects. We did not find evidence of publication bias by analyzing a funnel plot as well as Egger's and Begg's tests. While eight out of the nine studies included in this meta-analysis detected a statistically significant increase or decrease in serum levels of IGF-1 in Alzheimer's disease subjects, the analysis as a whole did not show a significant trend in either direction. Thus, IGF-1 level is likely a critical personalized factor. A large database of clinical trials is required for better understanding the relationship between IGF-1 levels and Alzheimer's disease.
DOI10.1371/journal.pone.0155733
URLView the original
Language英語
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Universidade de Macau
2.University of Toronto Faculty of Medicine
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GB/T 7714
Ostrowski P.P.,Barszczyk A.,Forstenpointner J.,et al. Meta-analysis of serum insulin-like growth factor 1 in Alzheimer's disease[J]. PLoS ONE,2016,11(5).
APA Ostrowski P.P.,Barszczyk A.,Forstenpointner J.,Zheng W.,&Feng Z.-P..(2016).Meta-analysis of serum insulin-like growth factor 1 in Alzheimer's disease.PLoS ONE,11(5).
MLA Ostrowski P.P.,et al."Meta-analysis of serum insulin-like growth factor 1 in Alzheimer's disease".PLoS ONE 11.5(2016).
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