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Differential regulation of neurogenesis by the two Xenopus GATA-1 genes
REN-HE XU1; JAEBONG KIM1; MASANORI TAIRA2; JIH-JING LIN1; CHAO-HUI ZHANG3; DVORA SREDNI4; TODD EVANS3; HSIANG-FU KUNG1
1997
Source PublicationMolecular and Cellular Biology
ISSN02707306
Volume17Issue:1Pages:436-443
Abstract

Previously, we have shown that the ventralizing factor bone morphogenetic protein 4 (BMP-4) can inhibit Xenopus neurogenesis. The erythroid transcription factor GATA-1 functions downstream of the BMP-4 signaling pathway and mediates BMP-4-induced erythropoiesis. We have found that similar to BMP-4, GATA-1b inhibits neuralization of Xenopus animal cap (AC) cells. The neural inhibition is not seen with GATA-1a, although both GATA-1a and GATA-1b RNAs are translated at the same efficiency and induce globin expression equally in AC cells. GATA-1b RNA injection into AC cells neither induces expression of Xbra (a general mesoderm marker) nor affects expression of XK81 (epidermal keratin) or BMP-4 and Xvent-1 (two ventral markers). These data suggest that GATA-lb retains the epidermal fate of the AC. Intact GATA-1b protein is required for both inhibition of neurogenesis and induction of globin expression. Our findings indicate that GATA-1b can function in ectoderm to specifically regulate neural inducing mechanisms, apparently related to the expression of chordin, a neuralizing gene. Furthermore, tadpole stage embryos injected with GATA-1b are devoid of all dorsoanterior structures including neural tissue. This report provides evidence that the two transcription factors, derived from a recent genome duplication, share a common biological activity (stimulation of erythropoiesis) while also exhibiting a distinct function (inhibition of neurogenesis).

DOI10.1128/MCB.17.1.436
URLView the original
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:A1997WA23300046
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Cited Times [WOS]:48   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorHSIANG-FU KUNG
Affiliation1.Laboratory of Biochemical Physiology, Division of Basic Sciences, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201
2.Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
3.Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461
4.Interdisciplinary Department, Bar Ilan University, Ramat Gan 52900, Israel
Recommended Citation
GB/T 7714
REN-HE XU,JAEBONG KIM,MASANORI TAIRA,et al. Differential regulation of neurogenesis by the two Xenopus GATA-1 genes[J]. Molecular and Cellular Biology,1997,17(1):436-443.
APA REN-HE XU.,JAEBONG KIM.,MASANORI TAIRA.,JIH-JING LIN.,CHAO-HUI ZHANG.,...&HSIANG-FU KUNG.(1997).Differential regulation of neurogenesis by the two Xenopus GATA-1 genes.Molecular and Cellular Biology,17(1),436-443.
MLA REN-HE XU,et al."Differential regulation of neurogenesis by the two Xenopus GATA-1 genes".Molecular and Cellular Biology 17.1(1997):436-443.
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