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Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand
TERI L. JONES1; LISA D. CHONG1; JAEBONG KIM2; REN-HE XU3; HSIANG-FU KUNG2; IRA O. DAAR1
1998-01-20
Source PublicationProceedings of the National Academy of Sciences of the United States of America
ISSN00278424
Volume95Issue:2Pages:576-581
Abstract

The erythropoietin-producing hepatocellular (Eph) family of ligands and receptors has been implicated in the control of axon guidance and the segmental restriction of cells during embryonic development. In this report, we show that ectopic expression of XLerk, a Xenopus homologue of the murine Lerk-2 (ephrin-B1) transmembrane ligand, causes dissociation of Xenopus embryonic blastomeres by the mid-blastula transition. Moreover, a mutant that lacks the extracellular receptor binding domain can induce this phenotype. The carboxyl-terminal 19 amino acids of the cytoplasmic domain of XLerk are necessary but not sufficient to induce cellular dissociation. Basic fibroblast growth factor, but not activin, can rescue both the loss of cell adhesion and mesoderm induction in ectodermal explants expressing XLerk. Collectively, these results show that the cytoplasmic domain of XLerk has a signaling function that is important for cell adhesion, and fibroblast growth factor signaling modulates this function.

DOI10.1073/pnas.95.2.576
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000071606000027
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Cited Times [WOS]:71   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorIRA O. DAAR
Affiliation1.Laboratory of Leukocyte Biology
2.Laboratory of Biochemical Physiology
3.Scientific Applications International Corporation, Frederick Intramural Research Support Program, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, MD 21702
Recommended Citation
GB/T 7714
TERI L. JONES,LISA D. CHONG,JAEBONG KIM,et al. Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand[J]. Proceedings of the National Academy of Sciences of the United States of America,1998,95(2):576-581.
APA TERI L. JONES,LISA D. CHONG,JAEBONG KIM,REN-HE XU,HSIANG-FU KUNG,&IRA O. DAAR.(1998).Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand.Proceedings of the National Academy of Sciences of the United States of America,95(2),576-581.
MLA TERI L. JONES,et al."Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand".Proceedings of the National Academy of Sciences of the United States of America 95.2(1998):576-581.
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