UM
Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis
Ying Peng1; K.H. Kok2,3; Ren-He Xu3; K.H.H. Kwok3; David Tay4; P.C.W. Fung2; Hsiang-fu Kung3; Marie C.M. Lin3
2000-09-29
Source PublicationFEBS Letters
ISSN00145793
Volume482Issue:1-2Pages:37-43
Abstract

We cloned a major isoform of Xenopus homologue of cold inducible RNA binding protein (CIRP), XCIRP-1. XCIRP-1 was neither cold inducible nor essential for cell division during early embryonic development. Suppression of XCIRP-1 dose dependently produced tailbuds with deformations of the brain and internal organs. The defects were XCIRP-1 specific as they could be rescued by sense transcript. Suppression of XCIRP-1 also disrupted the morphogenetic migration of the C3 blastomeres (lineaged to become the embryonic kidney, the pronephros). In animal cap explants, depletion of XCIRP-1 inhibited activin/retinoic acid induced expressions of pronephros related Xlim-1 and WT1 genes. These results suggest that XCIRP-1 is required for the specification and morphogenetic lineage migration of the pronephros. Copyright (C) 2000 Federation of European Biochemical Societies.

KeywordCdna Cloning Cold Inducible Rna Binding Protein Morphogenetic Movement Pronephros Xenopus Laevis
DOI10.1016/S0014-5793(00)02019-6
URLView the original
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS IDWOS:000089749100007
PublisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Fulltext Access
Citation statistics
Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Co-First AuthorYing Peng
Corresponding AuthorMarie C.M. Lin
Affiliation1.Department of Neurology, The First Military Medical University of China, Guangzhou, PR China
2.Division of Medical Physics, Department of Medicine, The University of Hong Kong, Hong Kong, PR China
3.WiCell Research Institute, 614 Walnut St., Madison, WI, USA
4.Department of Anatomy, The University of Hong Kong, Hong Kong, PR China
5.Institute of Molecular Biology, The University of Hong Kong, 8/F Kadoorie Biological Science Bldg., Pokfulam Rd, Hong Kong, PR China
Recommended Citation
GB/T 7714
Ying Peng,K.H. Kok,Ren-He Xu,et al. Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis[J]. FEBS Letters,2000,482(1-2):37-43.
APA Ying Peng.,K.H. Kok.,Ren-He Xu.,K.H.H. Kwok.,David Tay.,...&Marie C.M. Lin.(2000).Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis.FEBS Letters,482(1-2),37-43.
MLA Ying Peng,et al."Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis".FEBS Letters 482.1-2(2000):37-43.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ying Peng]'s Articles
[K.H. Kok]'s Articles
[Ren-He Xu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ying Peng]'s Articles
[K.H. Kok]'s Articles
[Ren-He Xu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ying Peng]'s Articles
[K.H. Kok]'s Articles
[Ren-He Xu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.