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Progresses and challenges in optimization of human pluripotent stem cell culture
Ge Lin; Ren-He Xu
2010-12-16
Source PublicationCurrent Stem Cell Research and Therapy
ISSN1574888X
Volume5Issue:3Pages:207-214
Abstract

The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pluripotency and differentiation, the development of animal-free, defined, and scalable culture systems, and some pioneering efforts to establish good manufactory practice facilities to derive and expand clinical-grade human ES cells and their derivatives. All of these advancements appear to be also applicable to the derivation and culture of human induced pluripotent stem cells, an ES cell-like cell type derived from somatic cells via reprogramming. This review attempts to summarize these progresses and discuss some of the remaining challenges. © 2010 Bentham Science Publishers Ltd.

KeywordGrowth Factors Human Embryonic Stem Cells Induced Pluripotent Stem Cells Tissue Culture
DOI10.2174/157488810791824548
URLView the original
Language英语
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000208262800002
PublisherBENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES
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Citation statistics
Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorRen-He Xu
AffiliationUniversity of Connecticut Stem Cell Institute, Department of Genetics and Developmental Biology, Farmington, Connecticut 06030, USA
Recommended Citation
GB/T 7714
Ge Lin,Ren-He Xu. Progresses and challenges in optimization of human pluripotent stem cell culture[J]. Current Stem Cell Research and Therapy,2010,5(3):207-214.
APA Ge Lin,&Ren-He Xu.(2010).Progresses and challenges in optimization of human pluripotent stem cell culture.Current Stem Cell Research and Therapy,5(3),207-214.
MLA Ge Lin,et al."Progresses and challenges in optimization of human pluripotent stem cell culture".Current Stem Cell Research and Therapy 5.3(2010):207-214.
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