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Isolation of scorpion (Androctonus amoreuxi) putative alpha neurotoxins and parallel cloning of their respective cDNAs from a single sample of venom
Chen T.; Folan R.; Kwok H.; O'Kane E.J.; Bjourson A.J.; Shaw C.
2003-09-15
Source PublicationRegulatory Peptides
ISSN01670115
Volume115Issue:2Pages:115-121
Abstract

The venoms of buthid scorpions are known to contain basic, single-chain protein toxins (alpha toxins) consisting of 60-70 amino acid residues that are tightly folded by four disulfide bridges. Here we describe isolation and sequencing of three novel putative alpha toxins (AamH1-3) from the venom of the North African scorpion, Androctonus amoreuxi, and subsequent cloning of their precursor cDNAs from the same sample of venom. This experimental approach can expedite functional genomic analyses of the protein toxins from this group of venomous animals and does not require specimen sacrifice for cloning of protein toxin precursor cDNAs. © 2003 Elsevier Science B.V. All rights reserved.

KeywordCdna Cloning Neurotoxin Precursor Scorpion Venom
DOI10.1016/S0167-0115(03)00146-0
URLView the original
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism ; Physiology
WOS SubjectEndocrinology & Metabolism ; Physiology
WOS IDWOS:000185868000005
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUlster University
Recommended Citation
GB/T 7714
Chen T.,Folan R.,Kwok H.,et al. Isolation of scorpion (Androctonus amoreuxi) putative alpha neurotoxins and parallel cloning of their respective cDNAs from a single sample of venom[J]. Regulatory Peptides,2003,115(2):115-121.
APA Chen T.,Folan R.,Kwok H.,O'Kane E.J.,Bjourson A.J.,&Shaw C..(2003).Isolation of scorpion (Androctonus amoreuxi) putative alpha neurotoxins and parallel cloning of their respective cDNAs from a single sample of venom.Regulatory Peptides,115(2),115-121.
MLA Chen T.,et al."Isolation of scorpion (Androctonus amoreuxi) putative alpha neurotoxins and parallel cloning of their respective cDNAs from a single sample of venom".Regulatory Peptides 115.2(2003):115-121.
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