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The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer
Zhao D.5; Guo L.4; Neves H.2; Yuen H.-F.3; Zhang S.-D.1; McCrudden C.M.1; Wen Q.1; Zhang J.4; Zeng Q.3; Kwok H.F.2; Lin Y.4
2015-07-13
Source PublicationOncoTargets and Therapy
ISSN11786930
Volume8Pages:1707-1717
Abstract

Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown. Recent reports have shown contradicting results on the role of PTP4A2 in breast cancer progression. Considering this, we aimed to investigate the prognostic value of PTP4A2 in five independent breast cancer data sets (minimum 198 patients per cohort, totaling 1,124 patients) in the Gene Expression Omnibus Database. We found that high expression of PTP4A2 was a favorable prognostic marker in all five independent breast cancer data sets, as well as in the combined cohort, with a hazard ratio of 0.68 (95% confidence interval =0.56–0.83; P,0.001). Low PTP4A2 expression was associated with estrogen receptor-negative tumors and tumors with higher histological grading; furthermore, low expression was inversely correlated with the expression of genes involved in proliferation, including MKI67 and the MCM gene family encoding the minichromosome maintenance proteins. These findings suggest that PTP4A2 may play a role in breast cancer progression by dysregulating cell proliferation. PTP4A2 expression was positively correlated with ESR1, the gene encoding estrogen receptor-alpha, and inversely correlated with EGFR expression, suggesting that PTP4A2 may be involved in these two important oncogenic pathways. Together, our results suggest that expression of PTP4A2 is a favorable prognostic marker in breast cancer.

KeywordBreast Cancer Minichromosome Maintenance Proteins Overexpression Prognostic Marker Ptp4a2 Survival
DOI10.2147/OTTS85899
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Oncology
WOS SubjectBiotechnology & Applied Microbiology ; Oncology
WOS IDWOS:000357878800004
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Queen's University Belfast
2.Universidade de Macau
3.A-Star, Institute of Molecular and Cell Biology
4.Fujian Normal University
5.Nanjing University of Aeronautics and Astronautics
Recommended Citation
GB/T 7714
Zhao D.,Guo L.,Neves H.,et al. The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer[J]. OncoTargets and Therapy,2015,8:1707-1717.
APA Zhao D..,Guo L..,Neves H..,Yuen H.-F..,Zhang S.-D..,...&Lin Y..(2015).The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer.OncoTargets and Therapy,8,1707-1717.
MLA Zhao D.,et al."The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer".OncoTargets and Therapy 8(2015):1707-1717.
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