UM  > 健康科學學院
CD133 in brain tumor: The prognostic factor
Li B.1; McCrudden C.M.3; Yuen H.F.2; Xi X.1; Lyu P.1; Chan K.W.4; Zhang S.D.5; Kwok H.F.1
Source PublicationOncotarget

CD133 has been shown to be an important stem cell factor that promotes glioma progression. However, the mechanism for CD133-mediated glioma progression has yet to be fully elucidated. In this study, we found that CD133 mRNA expression was a prognostic marker in three independent glioma patient cohorts, corroborating a putative role for CD133 in glioma progression. Importantly, we found that CD133 expression in glioma was highly correlated with the expression of HOX gene stem cell factors (HOXA5, HOXA7, HOXA10, HOXC4 and HOXC6). The expression of these HOX genes individually was significantly associated with survival. Interestingly, the prognostic significance of CD133 was dependent on the expression level of HOX genes, and vice versa. CD133 (p = 0.021) and HOXA7 (p = 0.001) were independent prognostic markers when the three glioma patient cohorts were combined (n = 231). Our results suggest that HOX genes may play a more important role in progression of glioma when CD133 expression is low. Furthermore, we showed that low-level expression of LIM2 in CD133-high glioma was associated with poorer survival, suggesting that LIM2 could be a therapeutic target for glioma expressing a high level of CD133. Connectivity mapping identified vinblastine and vincristine as agents that could reverse the CD133/HOX genes/LIM2-signature, and we confirmed this by in vitro analysis in glioma cell lines, demonstrating that CD133 and HOX genes were co-expressed and could be downregulated by vincristine. In conclusion, our data show that CD133 and HOX genes are important prognostic markers in glioma and shed light on possible treatment strategies for glioma expressing a high level of CD133.

KeywordBrain Tumor Cd133 Hox Lim2 Stem Cell
URLView the original
Indexed BySCI
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000394187400042
Fulltext Access
Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Universidade de Macau
2.A-Star, Institute of Molecular and Cell Biology
3.Queen's University Belfast
4.The University of Hong Kong
5.Ulster University
Recommended Citation
GB/T 7714
Li B.,McCrudden C.M.,Yuen H.F.,et al. CD133 in brain tumor: The prognostic factor[J]. Oncotarget,2017,8(7):11144-11159.
APA Li B..,McCrudden C.M..,Yuen H.F..,Xi X..,Lyu P..,...&Kwok H.F..(2017).CD133 in brain tumor: The prognostic factor.Oncotarget,8(7),11144-11159.
MLA Li B.,et al."CD133 in brain tumor: The prognostic factor".Oncotarget 8.7(2017):11144-11159.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li B.]'s Articles
[McCrudden C.M.]'s Articles
[Yuen H.F.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li B.]'s Articles
[McCrudden C.M.]'s Articles
[Yuen H.F.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li B.]'s Articles
[McCrudden C.M.]'s Articles
[Yuen H.F.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.