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CD133 in brain tumor: The prognostic factor
Li B.1; McCrudden C.M.3; Yuen H.F.2; Xi X.1; Lyu P.1; Chan K.W.4; Zhang S.D.5; Kwok H.F.1
2017
Source PublicationOncotarget
ISSN19492553
Volume8Issue:7Pages:11144-11159
Abstract

CD133 has been shown to be an important stem cell factor that promotes glioma progression. However, the mechanism for CD133-mediated glioma progression has yet to be fully elucidated. In this study, we found that CD133 mRNA expression was a prognostic marker in three independent glioma patient cohorts, corroborating a putative role for CD133 in glioma progression. Importantly, we found that CD133 expression in glioma was highly correlated with the expression of HOX gene stem cell factors (HOXA5, HOXA7, HOXA10, HOXC4 and HOXC6). The expression of these HOX genes individually was significantly associated with survival. Interestingly, the prognostic significance of CD133 was dependent on the expression level of HOX genes, and vice versa. CD133 (p = 0.021) and HOXA7 (p = 0.001) were independent prognostic markers when the three glioma patient cohorts were combined (n = 231). Our results suggest that HOX genes may play a more important role in progression of glioma when CD133 expression is low. Furthermore, we showed that low-level expression of LIM2 in CD133-high glioma was associated with poorer survival, suggesting that LIM2 could be a therapeutic target for glioma expressing a high level of CD133. Connectivity mapping identified vinblastine and vincristine as agents that could reverse the CD133/HOX genes/LIM2-signature, and we confirmed this by in vitro analysis in glioma cell lines, demonstrating that CD133 and HOX genes were co-expressed and could be downregulated by vincristine. In conclusion, our data show that CD133 and HOX genes are important prognostic markers in glioma and shed light on possible treatment strategies for glioma expressing a high level of CD133.

KeywordBrain Tumor Cd133 Hox Lim2 Stem Cell
DOI10.18632/oncotarget.14406
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000394187400042
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Universidade de Macau
2.A-Star, Institute of Molecular and Cell Biology
3.Queen's University Belfast
4.The University of Hong Kong
5.Ulster University
Recommended Citation
GB/T 7714
Li B.,McCrudden C.M.,Yuen H.F.,et al. CD133 in brain tumor: The prognostic factor[J]. Oncotarget,2017,8(7):11144-11159.
APA Li B..,McCrudden C.M..,Yuen H.F..,Xi X..,Lyu P..,...&Kwok H.F..(2017).CD133 in brain tumor: The prognostic factor.Oncotarget,8(7),11144-11159.
MLA Li B.,et al."CD133 in brain tumor: The prognostic factor".Oncotarget 8.7(2017):11144-11159.
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